专利号:US-5248815-A 优先权日:1991-12-27 标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines 发明人:PARADIES HENRICH H 权利人:PARADIES HENRICH H 摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.
专利号:WO-2022224090-A1 优先权日:2021-04-20 标题 :Method for the physical synthesis of metallic nanoparticles 发明人:Ã?VILA BERNAL ALBA GRACIELA; PÉREZ TABORDA JAIME ANDRÉS; LANZA BAYONA GUSTAVO ADOLFO 权利人:UNIV LOS ANDES 摘要:The present invention relates to a method for the physical synthesis of metallic nanoparticles, which comprises: (a) depositing a metallic film on a substrate of irregularly oriented salt crystal; and (b) heat-treating the metallic film deposited on the substrate until metallic nanoparticles form. This method makes it possible to obtain nanoparticles that are immobilised on a substrate and completely free of stabilising agents or surface ligands, in addition to nanoparticles in suspension or dry nanoparticles. The method also enables the production of nanoparticles having different sizes and diverse morphologies by adjusting the surface characteristics of the substrate, the characteristics of the metallic film and the thermal conditions established during the nanoparticle formation steps.
专利号:US-2008214827-A1 优先权日:2004-02-03 标 题:Synthesis of Cyanoimino-Benzoimidazoles 发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN 权利人:EURO CELTIQUE SA 摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
专利号:US-7524990-B2 优先权日:2004-02-17 标题:Synthesis of sterically hindered secondary aminoether alcohols 发明人:SISKIN MICHAEL; KATRITZKY ALAN ROY; KIRICHENKO KOSTYANTYN MYKOLAYEVICH; BISHOP ADEANA RICHELLE; ELIA CHRISTINE NICOLE 权利人:EXXONMOBIL RES & ENG CO 摘要:Severely sterically hindered secondary aminoether alcohols are prepared by reacting organic carboxylic, organic carboxylic acid halides, acid anhydrides or a ketene with an alkyl, alkaryl or alkylhalo sulfonate to yield a sulfonic-carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane, yielding a cleavage product which cleavage product is then aminated with an alkylamine and hydrolyzed with base to yield the severely sterically hindered secondary aminoether alcohol.
专利号:US-12187735-B2 优先权日:2018-09-17 标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-2025092058-A1 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
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合成参考文献
摘要:Research Progress in Organic-Biological and Medicinal Chemistry., 2(282), 1970