CAS: 69999-16-2; 2,3-Dihydrobenzofuranyl-5-Acetic Acid

相似化合物

215057-28-6 69999-18-4 87776-76-9

上下游产品

CAS号97483-11-9 2-(2,3-Dihydro-... | CAS号496-16-2 2,3-二氢苯并呋喃 | CAS号90843-31-5 5-乙酰基-2,3-二氢苯并[b]呋喃 | CAS号188862-35-3 5-(溴甲基)苯并呋喃 | CAS号87776-76-9 2,3-二氢-5-苯并呋喃乙醇 | CAS号155852-41-8 2,3-二氢-5-苯并呋喃乙酸甲酯 | CAS号97483-17-5 替呋酸

2,3-二氢苯并呋喃置于三氯化铝,硫酸,水,对甲苯磺酸,Sulfur,溶剂黄146体系中,用 二氯甲烷 作为反应溶剂,化学反应 9.5H,反应生成 2,3-二氢苯并呋喃-5-乙酸
参考文献:镇痛和抗炎的7-芳酰基苯并呋喃-5-基乙酸和7-芳酰基苯并噻吩-5-基乙酸.
标题:镇痛和抗炎的7-芳酰基苯并呋喃-5-基乙酸和7-芳酰基苯并噻吩-5-基乙酸.
摘要:合成了许多7-苯甲酰基苯并呋喃-5-基乙酸和7-苯甲酰基苯并噻吩-5-基乙酸.在大鼠足水肿抗炎试验中,该化合物的效力通常仅为苯基丁a的1/2至3倍.但是,它们显示出更大的镇痛药活性.最具活性的化合物是7-[4-(甲硫基)-苯甲酰基]苯并呋喃-5-基乙酸(5G),在小鼠扭体镇痛试验中的效力为阿司匹林的57倍.在高达90 Mg / Kg的剂量下,该化合物实际上不会在大鼠中引起胃溃疡.
DOI:10.1021/jm00161A030

专利信息

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2020317627-A1
优先权日:2019-04-05
标 题:Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical c-h amination

专利号:US-5302595-A
优先权日:1988-10-04
标题:Muscarinic receptor antagonists
发明人：CROSS PETER E; MACKENZIE ALEXANDER R
权利人:PFIZER
摘要:Compounds of the formula I ##STR1## wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

专利号:CN-102731449-A
优先权日:2011-04-01
标题 :A kind of synthesis technology of dalfinacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran

专利号:CN-102731449-B
优先权日:2011-04-01
标 题 :A kind of synthesis technology of dalfinacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran