CAS: 6719-21-7; 2-Amino-2-Cyanoacetamide

相似化合物

62009-47-6 35320-22-0 7324-05-2

上下游产品

CAS号32683-02-6 2-氨基-2-氰基乙酸乙酯 | CAS号7440-06-4 铂 | CAS号105-34-0 氰乙酸甲酯 | CAS号127745-39-5 2-cyano-2-oximi... | CAS号89765-49-1 ethyl (E)-2-cya... | CAS号144-55-8 碳酸氢钠 | CAS号3849-20-5 2-氰基-2-(羟基亚氨基)乙酰胺 | CAS号360-97-4 5-氨基-4-甲酰胺咪唑 | CAS号5539-46-8 5-胺基噻唑-4-甲酰胺 | CAS号127574-36-1 5-amino-1-benzh... | CAS号14056-39-4 N2-乙酰基-3-次氮基丙氨酰胺 | CAS号34407-35-7 2-cyano-2-(1-et... | CAS号64995-55-7 5-amino-1-pheny... | CAS号52868-71-0 5-amino-2-(meth... | CAS号3815-69-8 5-amino-1-benzy... | CAS号37800-98-9 5-氨基-2-甲基-1H-咪唑-4-羧胺 | CAS号37642-55-0 1H-Imidazole-4-...

Nitrosocyanoacetamide置于铂 氢气体系中,用 甲醇,水,异丙醇 作为反应溶剂,以1%的收率获得产物2-氨基-2-氰基乙酰胺
参考文献:Method Of Producing Aminocyanoacetamide
标题:Method Of Producing Aminocyanoacetamide
摘要:通过目前的方法,首次可以在工业上应用的过程可用于直接生产氨基氰乙酰胺.该方法基于氰乙酰胺与亚硝酸盐在约ph 2的条件下反应形成亚硝基氰乙酰胺,然后通过催化氢化将亚硝基氰乙酰胺转化为氨基氰乙酰胺.

专利信息

专利号:US-7737284-B2
优先权日:2001-01-18
标题 :Synthesis of temozolomide and analogs
发明人：KUO SHEN-CHUN; MAS JANET L; HOU DONALD CHEN-TUNG
权利人:SCHERING PLOUGH CORP
摘要:This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

专利号:US-6849735-B1
优先权日:2000-06-23
标 题:Methods of synthesis for 9-substituted hypoxanthine derivatives
发明人：GLASKY ALVIN J; BOLLINGER HEINRICH; MUELLER HANS RUDOLF
权利人:MERCK EPROVA AG
摘要:An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoformate to form a 9-substituted hypoxanthine compound substituted at the 9-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; and (5) hydrolyzing the ester of the optionally esterified benzoyl group if present.

专利号:US-2002156277-A1
优先权日:2001-04-20
标题 :Synthesis and methods of use of purine analogues and derivatives
发明人：FICK DAVID B; FOREMAN MARK M; GLASKY ALVIN J
摘要:A purine derivative or analogue comprises a 9-atom bicyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y 1 )—D, where Y 1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption or blood-brain barrier penetration of the derivative or analogue. The moiety A has a six-membered ring fused to a five-membered ring. The moiety A can have one, two, or three nitrogen atoms in the five membered ring and has two nitrogen atoms in the six-membered ring. The moiety A can be a purine moiety. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity.

专利号:US-2005131227-A1
优先权日:2001-01-18
标 题:Synthesis of temozolomide and analogs

专利号:US-2006229456-A1
优先权日:2001-01-18
标 题:Synthesis of Temozolomide and analogs

专利号:WO-02057269-A1
优先权日:2001-01-18
标题:Synthesis of temozolomide and analogs