2,4-二硝基咪唑置于氢溴酸,尿素体系中,用 氯苯 作为反应溶剂,化学反应生成 2-溴-4-硝基咪唑 参考文献: Methods For The Production Of 2-Halo-4-Nitroimidazole And Intermediates Thereof[fr] Procédés Pour La Fabrication De 2-Halo-4-Nitroimidazole Et Leurs Intermédiaires 标题: Methods For The Production Of 2-Halo-4-Nitroimidazole And Intermediates Thereof[fr] Procédés Pour La Fabrication De 2-Halo-4-Nitroimidazole Et Leurs Intermédiaires 摘要:本发明涉及一种生产2-卤代-4-硝基咪唑及其中间体的方法.此外,本发明涉及一种生产1,4-二硝基咪唑的生产过程,包括将4-硝基咪唑进行硝化反应.此外,本发明涉及一种生产4-硝基咪唑的生产过程,包括将咪唑进行硝化反应.
专利号:US-8129544-B2 优先权日:2002-10-15 标题:1-substituted-4-nitroimidazole compound and method for preparing the same 发明人:GOTO FUMITAKA; TAKEMURA NORIAKI; OTANI TADAAKI; HASEGAWA TAKESHI; TSUBOUCHI HIDETSUGU; UTSUMI NAOTO; FUJITA SHIGEKAZU; KURODA HIDEAKI; SHITSUTA TAKUYA; SASAKI HIROFUMI 权利人:GOTO FUMITAKA; TAKEMURA NORIAKI; OTANI TADAAKI; HASEGAWA TAKESHI; TSUBOUCHI HIDETSUGU; UTSUMI NAOTO; FUJITA SHIGEKAZU; KURODA HIDEAKI; SHITSUTA TAKUYA; SASAKI HIROFUMI; OTSUKA PHARMA CO LTD 摘要:The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, n n(wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula —CH 2 R A ; X is a halogen atom or a group of the formula —S(O)n-R 1 ) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.
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