CAS: 643-93-6; 3-Methylbiphenyl

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CAS号625-95-6 3-甲碘苯 | CAS号98-80-6 苯硼酸 | CAS号591-17-3 3-溴甲苯 | CAS号71-43-2 苯 | CAS号3955-72-4 1-methyl-4-(3-m... | CAS号2996-92-1 苯基三甲氧基硅烷 | CAS号591-50-4 碘苯 | CAS号17933-03-8 3-甲基苯硼酸 | CAS号108-41-8 间氯甲苯 | CAS号100-59-4 苯基氯化镁 | CAS号23948-77-8 2-([1,1'-联苯]-3-基)乙酸 | CAS号69605-90-9 3-联苯甲醇 | CAS号69314-47-2 3-甲基-4-硝基联苯 | CAS号63019-98-7 2H,4h,5h,6h,7h,... | CAS号716-76-7 3-苯基苯甲酸 | CAS号14704-31-5 3-苯基苄基溴 | CAS号1204-60-0 联苯基-3-甲醛 | CAS号24973-50-0 [1, 1'-联苯]-3-甲腈

二苯并噻吩置于正丁基锂,Sodium,1,1,2,2-四苯乙烯体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 14.5H,反应生成 3-甲基联苯
参考文献:Active-Alkali Metal Promoted Reductive Desulfurization Of Dibenzothiophene And Its Hindered Analogues
标题:Active-Alkali Metal Promoted Reductive Desulfurization Of Dibenzothiophene And Its Hindered Analogues
摘要:Dibenzothiophene And Some Related Organosulfur Compounds Are Efficiently Reductively Desulfurized Under Mild Reaction Conditions,With Na And/or Li Metal In The Presence Of A Catalytic Amount Of Tetraphenylethylene In Thf At Room Temperature. This Simple Methodology Was Applied To The Synthesis Of Several Substituted Biphenyls,Thus Realizing A Connection Between The Directing Properties Of The Sulfur Atom Of Dibenzothiophene And The Efficiency Of 1,2-Dianions Of Tetraphenylethane As Homogenous Electron Transfer Reagents. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2012.10.044

专利信息

专利号:US-9012625-B2
优先权日:2009-04-07
标 题 :Method for the synthesis of a trisaccharide
发明人：DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS
权利人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS; GLYCOM AS
摘要:The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.

专利号:US-10005807-B2
优先权日:2013-04-12
标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
发明人：CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:WO-2014167537-A1
优先权日:2013-04-12
标题:Synthesis of sialylated/fucosylated oligosaccharides
发明人：KHANZHIN NIKOLAY; CHASSAGNE PIERRE; HEDEROS MARKUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10, preferably 2 or 3, R 1 is selected from sialyl moiety, -SO 3 H and -CH(R 5 )-COOH wherein R 5 is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that one but only one of R 3 and R 4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:US-9102966-B2
优先权日:2010-07-16
标 题:Synthesis of sialooligosaccharide derivatives
发明人：SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS
权利人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS; GLYCOM AS
摘要:The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X 1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R 1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

专利号:US-2014228554-A1
优先权日:2011-03-18
标 题:Synthesis of new fucose-containing carbohydrate derivatives
发明人：CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY
权利人:GLYCOM AS; GLYCOM AS
摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.

专利号:US-2014303363-A1
优先权日:2011-12-09
标题 :Preparation and Use of Isolactosamine and Intermediates therefor
发明人：HEDEROS MARKUS; RISINGER CHRISTIAN; BOUTET JULIEN; DEKANY GYULA
权利人:GLYCOM AS
摘要:The invention relates to providing isolactosamine (Galβ1-3GlcNH 2 , formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. The synthesis of isolactosamine and its use in the synthesis of lacto-N-biose containing oligosaccharides are also disclosed.