CAS: 62396-48-9; N-Boc-D-Aspartic Acid

该化合物是D-阻隔酸的一种受保护衍生物,广泛用于peptide合成和有机化学.乙型丁氧碳基(Boc)组是氨基功能的强大保护组,确保多步合成过程中选择性反应.该化合物对于培养具有立体化学完整性至关重要的手性中间体和生物活性peptides特别有用.在各种反应条件下,它高纯度和稳定性使它成为研究人员的首选.此外,乙型丁氧碳基(Boc)组与标准的混合剂相容,有助于有效融入peptited链.该产品通常用于药物研究和不对称合成应用.

结构式图片

相似化合物

13726-67-5 1152-61-0 119062-05-4

上下游产品

(2R)-aspartic acid tert-butyl dicarbonatedi-tert-butyl dicarbonate2-tert-Butoxycarbonylamino-succinic acid dibenzyl ester (R)-2-tert-Butoxycarbonylamino-succinic acid 1-(9H-fluoren-9-ylmethyl) ester 30H29FN4O5SC30H29FN4O5S 30H29FN4O5SC30H29FN4O5S

合成工艺路线路线简述

    📜Boc-Dl-天冬氨酸,苯甲醇 反应生成 Boc-D-天冬氨酸
    参考文献:Cantacuzene,D.;Pascal,F.;Guerreiro,C.,Tetrahedron,43,(1987) N 8,1823-1826
    标题:Cantacuzene,D.;Pascal,F.;Guerreiro,C.,Tetrahedron,43,(1987) N 8,1823-1826

    海关参考信息

    专利信息


    专利号:US-6359144-B1
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
    权利人:LION BIOSCIENCE AG
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

    专利号:US-2022185846-A1
    优先权日:2019-03-28
    标 题:Methods for synthesizing beta-homoamino acids
    发明人:MANTHATI SURESH KUMAR; BHANDARI ASHOK; MASJEDIZADEH MOHAMMAD REZA
    权利人:PROTAGONIST THERAPEUTICS INC
    摘要:Methods of making β-homoamino acids as intermediate for synthesis of peptide monmer and dimer α4β7-antagonists are disclosed. The disclosed methods include solid phase and solution phase methods.

    专利号:CN-103159638-A
    优先权日:2013-03-15
    标 题:Synthesis of N-methyl-D-aspartic acid

    专利号:US-7179794-B2
    优先权日:1998-06-08
    标题 :Multivalent macrolide antibiotics
    发明人:GRIFFIN JOHN H; PACE JOHN L
    权利人:THERAVANCE INC
    摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1163/156856789x00096
    摘要:Rhofir C, Vocelle D, Sandorfy C. Ftir study of the protonation of a retinyl schiff base in chloroform/methanol mixtures. Research on Chemical Intermediates. 1989 Jun;12(2):131–9. doi: 10.1163/156856789x00096.
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