间硝基苯酚置于potassium Carbonate,溶剂黄146体系中,用 乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.33H,反应生成 间氨基苯乙醚 参考文献:[cp*rhcl2]2-Catalyzed Alkyne Hydroamination To 1,2-Dihydroquinolines 标题:[cp*rhcl2]2-Catalyzed Alkyne Hydroamination To 1,2-Dihydroquinolines 摘要:[cp*rhcl2](2) Catalyzes The Formation Of 1,2-Dihydroquinolines From The Reaction Of Two Terminal Alkynes And An Aniline. This Reaction Is Believed To Proceed Via An Alkyne Hydroamination Followed By An Alkyne Insertion.. DOI:10.1021/om501253V
专利号:US-4871873-A 优先权日:1988-03-18 标 题:Process for synthesis of arylglyoxal arylimines 发明人:DESMOND RICHARD; MILLS SANDER G; VOLANTE RALPH P; SHINKAI ICHIRO 权利人:MERCK & CO INC 摘要:A process for producing arylglyoxal arylimine intermediates, by the DMSO/HBr oxidation of arylmethylketones. The imine compounds are intermediates in the synthesis of carbapenem antibiotics, i.e. imipenem.
专利号:US-4719053-A 优先权日:1980-08-01 标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates 发明人:SCHLAEFER LUDWIG; HAEHNLE REINHARD 权利人:HOECHST AG 摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.
专利号:US-2022281888-A1 优先权日:2019-09-25 标题:Bicyclic carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT; GORECZNY GREGORY 权利人:NIROGY THERAPEUTICS INC 摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6417195-B1 优先权日:1999-02-22 标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAL 权利人:LION BIOSCIENCE AG 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
摘要:Hagen, T. J.; Helgren, T. R., Science of Synthesis Knowledge Updates, (2015) 2, 155. 摘要:N. F. Hall and M. R. Sprinkle. J. Am. Chem. Soc. 54, 3469 (1932). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 参考文献:10.1107/s1600536810022427 摘要:Aziz-Ur-Rehman, Siddiqa A, Akkurt M, Abbasi MA, Jahangir M, Khan IU. N-(3-Eth-oxy-phen-yl)-4-methyl-benzene-sulfonamide. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 16;66(Pt 7):o1682.