专利号:US-9920160-B2 优先权日:2014-09-03 标题 :Method for synthesis of polymer containing multiple epoxy groups 发明人:GAO CHAO; ZHENG YAOCHEN; PENG LI; CAI SHENGYING; WENG ZHULIN 权利人:UNIV ZHEJIANG 摘要:A method for a synthesis of a polymer containing multiple epoxy groups includes steps of: under protection of nitrogen or argon, with a photosensitive free radical initiator under an ultraviolet light irradiation, initiating a mixture of a dithiol compound and alkynyl glycidyl ether or other alkynyl-containing compounds to proceed a thiol-yne polymerization, so as to obtain the polymer. The number of the epoxy groups is able to be adjusted through changing a type of a dithiol monomer, a mixing ratio of the dithiol monomer, and a mixing ratio between the alkynyl glycidyl ether and other alkynyl compounds. The present invention has advantages of: fast reaction, convenient process, easy post-processing, a large number of the epoxy groups, and adjustable and controllable content. The obtained polymer has a wide potential application in fields of coating, adhesive, ink, encapsulating material, resin for composite material, additive, high performance material, function material, and so on.
专利号:US-2024208898-A1 优先权日:2021-03-25 标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents 发明人:KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T 权利人:DANA FARBER CANCER INST INC 摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.
专利号:WO-03061385-A1 优先权日:2002-01-17 标题:Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents 发明人:AN HAOYUN; HONG ZHI; SMITH KENNETH; DING YILI; GIRARDET JEAN-LUC 权利人:RIBAPHARM INC; AN HAOYUN; HONG ZHI; SMITH KENNETH; DING YILI; GIRARDET JEAN-LUC 摘要:Tricyclic nucleoside libraries and library compounds are prepared using combinatorial chemistry and non-combinatorial chemistry methods. Contemplated library compounds are particularly useful in inhibition of viral propagation, and particularly of viral propagation of the HCV virus.
专利号:US-2017044304-A1 优先权日:2014-09-03 标 题:Method for synthesis of polymer containing multiple epoxy groups
专利号:JP-2024512568-A 优先权日:2021-03-25 标 题:Enamine N-oxide: synthesis and application of hypoxia-responsive prodrugs and contrast agents
[参考文献]: Lingling Peng, Et Al. Transition-Metal-Catalyzed Rearrangement Of Allenyl Sulfides: A Route To Furan Derivatives. Angew Chem Int Ed Engl. 2007;46(11):1905-8.
合成参考文献
摘要:Negishi, E.; Wang, G., Science of Synthesis, (2010) 47, 978. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 405. 摘要:Hou, X.-L.; Peng, X.-S.; Yeung, K.-S.; Wong, H. N. C., Science of Synthesis Knowledge Updates, (2011) 2, 322. 摘要:Ulfkjær, A.; Pittelkow, M., Science of Synthesis Knowledge Updates, (2018) 1, 158. 摘要:Fringuelli, F.; Piermatti, O., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 497.