专利号:US-5210314-A 优先权日:1990-05-03 标题:Preparation of canthaxanthin and astaxanthin 发明人:ERNST HANSGEORG; PAUST JOACHIM; HOFFMANN WERNER 权利人:BASF AG 摘要:A process for preparing canthaxanthin (Ia) and astaxanthin (Ib) of the formula I ##STR1## n where R is H (a) or OH (b), comprises reacting a tertiary alcohol of the formula II ##STR2## n where R is H (a) or OH (b), with trifluoroacetic acid, reacting the resulting novel trifluoroacetate of the formula III ##STR3## n with triphenylphosphine, and reacting the resulting novel triphenylphosphonium trifluoroacetate of the formula IV ##STR4## n with 2,7-dimethyl-2,4,6-octatriene-1,8-dial under the conditions of a Wittig synthesis. The present invention also relates to the novel trifluoroacetates of the formula III and the corresponding triphenylphosphonium trifluoroacetates of the formula IV.
专利号:US-8969395-B2 优先权日:2009-05-20 标题 :Triterpenoid derivatives useful as antiproliferative agents 发明人:RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA 权利人:RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA; UNIV DE COIMBRA 摘要:Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth and for treating cancer and other proliferative diseases, more particularly for treating leukemia, liver, cervical, colon and prostate cancer. The present invention also relates to the synthesis of these compounds and to pharmaceutical compositions which contain them.
参考文献:10.1007/bf02976628 摘要:Suh J, Jo Y, Kim ND, Bae SJ, Jung JH, Im KS. Cytotoxic constituents of the leaves of Ixeris sonchifolia. Arch Pharm Res. 2002 Jun;25(3):289–92. doi: 10.1007/bf02976628.