CAS: 433-06-7; 2,2,2-Trifluoroethyl 4-Methylbenzenesulfonate

上下游产品

2,2,2-trifluoroethanol p-toluenesulfonyl chloride 1H-imidazole N-benzyl-N'-(4-toluenesulfonyloxy)diimide N-oxide 1,1,1,2-tetrafluoroethane 1,1,1-trifluoro-2-iodoethane Cyclohexylidene-(toluene-4-sulfonyloxy)-acetic acid trans-cinnamic acidα-(toluene-4-sulfonyloxy)-trans-cinnamic acid

1-[hydroxy(Tosyloxy)Iodo]-1H,1H-Perfluoroethane 以 二氯甲烷,乙腈 作为反应溶剂,化学反应 10.0H,反应生成 2,2,2-三氟乙基 对甲苯磺酸酯
参考文献:环状烯胺的新型三氟乙基碘鎓盐及其热分解
标题:环状烯胺的新型三氟乙基碘鎓盐及其热分解
摘要:使1-[羟基(甲苯磺酰基氧基)碘]-2,2,2-三氟乙烷与环状烯胺酮反应,得到稳定的碘代甲苯磺酸盐.它们温和的热解提供了碘烯酮和甲苯磺酸2,2,2-三氟乙基酯.
DOI:10.1016/s0040-4039(97)10232-5

专利信息

专利号:WO-2011101864-A1
优先权日:2010-02-17
标题 :Novel process for the synthesis of phenoxyethyl derivatives
发明人：JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA
权利人:PANACEA BIOTEC LTD; JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA
摘要:The present invention provides an improved process for the synthesis of 2-[2- (2,2,2-trifluoroethoxy)phenoxy]ethanol intermediate, its derivatives and/or its pharmaceutically acceptable salts, useful in the synthesis of α-1 adrenoceptor blockers such as silodosin.

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D†). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-5283336-A
优先权日:1992-09-08
标 题 :Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline
发明人：FIELD GEORGE; HAMMOND PETER R
权利人:US ARMY
摘要:Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

专利号:US-10717707-B2
优先权日:2014-08-07
标 题 :Synthesis of 2,2,2-trifluoroethanethiol
发明人：SYVRET ROBERT GEORGE; POLSZ CRAIG ALAN; SWAN DANA LEE; SRINIVAS VIJAY R
权利人:ARKEMA INC
摘要:A method of making CF3CH2SH, comprising a step of reacting CF3CH2X, wherein X is halide or tosylate, with MSH, where M is an alkali metal such as Na or K, to yield CF3CH2SH.

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.