CAS: 3934-29-0; (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-Fluorotetrahydro-2H-Pyran-3,4,5-Triyl Triacetate

相似化合物

2106-10-7 2823-44-1 174511-17-2

上下游产品

β-D-mannopyranose pentaacetate 2,3,4,6-tetra-O-acetyl-D-mannopyranose phenyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-mannopyranoside β-1-deoxy-1-C-(phenylthio)-2,3,4,5-tetra-O-acetyl-D-mannopyranose α-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl esterNα-fluoren-9-ylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine benzyl ester α-(9-fluorenylmethoxycarbonyl)-3-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonineNα-(9-fluorenylmethoxycarbonyl)-3-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-threonine methyl 5-[4-(α-D-mannopyranosyloxy)phenyl]-2-pyridinecarboxylate 5-[4-(α-D-mannopyranosyloxy)phenyl]-picolinic acid

1,2,3,4,6-Alpha-D-葡萄糖五乙酸酯置于吡啶,氢氟酸体系中,化学反应 7.0H,以83%的收率获得2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖酰氟
参考文献:Synthesis Of 2-Deoxy-2,2-Difluoro-α-Maltosyl Fluoride And Its X-Ray Structure In Complex With Streptomyces Coelicolor Glgei-V279S
标题:Synthesis Of 2-Deoxy-2,2-Difluoro-α-Maltosyl Fluoride And Its X-Ray Structure In Complex With Streptomyces Coelicolor Glgei-V279S
摘要:结核分枝杆菌(mtb)的glge是一个经遗传验证的结核病药物靶点,参与α-葡聚糖生物合成.本文描述的streptomyces Coelicolor(sco)的glgei-V279S变体被用作基于结构的抑制剂设计的模型酶.
Doi:10.1039/c5Ob00867K

专利信息

专利号:US-5218097-A
优先权日:1988-12-07
标题:Process for the preparation of protected mono-sugar and oligo-sugar halides
发明人：ERNST BEAT
权利人:CIBA GEIGY CORP
摘要:The reaction of protected monosaccharides or oligosaccharides or protected monosaccharide and oligosaccharide derivatives containing an anomeric hydroxyl group with secondary α-haloenamines affords high yields of protected glycosyl halides, which are valuable intermediates for the introduction of sugar groups in the synthesis of oligosaccharides, glycolipids or glycopeptides.