📜4-氨甲基苯甲酸置于sodium Hydroxide体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应生成 4-[(叔丁氧羰基氨基)甲基]苯甲酸 参考文献:Pyrimidine Derivatives And Methods Of Making And Using These Derivatives 标题:Pyrimidine Derivatives And Methods Of Making And Using These Derivatives 摘要:本发明揭示了化合物及其药用可接受的盐,用于治疗患有疾病的患者.这些疾病包括癌症,以及免疫受损患者中由肺孢子虫和弓形虫引起的继发性感染.这些化合物本身,制备这些化合物的方法以及使用这些化合物的方法都被揭示.
专利号:US-11679168-B2 优先权日:2018-09-14 标 题 :Caspase-3-triggered molecular self-assembling PET probes and uses thereof 发明人:RAO JIANGHONG; CHENG YUNFENG; CHEN MIN; XIE JIANGHANG; CHEN ZIXIN 权利人:UNIV LELAND STANFORD JUNIOR; THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIV 摘要:Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.
专利号:US-5916899-A 优先权日:1996-10-18 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:US-6417195-B1 优先权日:1999-02-22 标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAL 权利人:LION BIOSCIENCE AG 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
专利号:US-5874443-A 优先权日:1995-10-19 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:US-8450529-B2 优先权日:2008-10-02 标 题:Branched polyamines and formulations thereof for use in medical devices 发明人:KAPIAMBA MBIYA 权利人:KAPIAMBA MBIYA; COVIDIEN LP 摘要:The present disclosure provides for the synthesis of branched polyamines. In embodiments, branched polyamines may be formed by reacting a branched polyol with a nitroaryl carboxylic acid to form a nitrobenzoyl ester which, in turn, may then be subjected to a hydrogenating step to form the branched polyamine. The resulting branched polyamine may then be reacted with another hydrogel precursor to form a hydrogel.
专利号:WO-0102375-A1 优先权日:1999-07-01 标 题:Process for synthesizing oxadiazoles 发明人:DENER JEFFREY MARK; LY CUONG QUOC 权利人:AXYS PHARM INC; DENER JEFFREY MARK; LY CUONG QUOC 摘要:The present invention relates to a process for the synthesis of a single as well as large array of oxadiazole based organic compounds. These oxadiazole based organic compounds are represented by compounds of formula (I).
参考文献:10.1557/s43579-025-00869-9 摘要:Nishikawa Y, Kanao Y, Nakano K. Precise synthesis of poly(propylene carbonate)-block-poly(α-amino acid)s via copolymerization of propylene oxide with carbon dioxide and ring-opening polymerization of α-amino acid N-thiocarboxyanhydrides. MRS Commun. 2025 Nov 23;15(6):1229–35. doi: 10.1557/s43579-025-00869-9.