十二烷基二甲基铵溴化物置于氮体系中,用 水,氯仿 用作溶剂,化学反应 16.0H,反应生成双十烷基二甲基溴化铵 参考文献:Protein And Peptide Delivery To Mammalian Cells In Vitro 标题:Protein And Peptide Delivery To Mammalian Cells In Vitro 摘要:本文描述了用于体外哺乳动物细胞中蛋白质和肽的传递的组合物和方法.具体来说,本文描述了由多肽的非共价疏水化和可逆疏水修饰形成的多肽-表面活性剂复合物.该组合物可用于向细胞传递带正电荷,负电荷和中性电荷的多肽.
专利号:US-2007260089-A1 优先权日:2004-03-26 标 题 :Method for the Synthesis of Quaternary Ammonium Compounds and Compositions Thereof 发明人:SAUER JOE D; KNIGHT CHRISTOPHER S; EVERLY CHARLES R; CHENG CHI HUNG 权利人:ALBEMARLE CORP 摘要:A novel manufacturing process is described for producing quaternary ammonium compounds having a selected anion, which may be useful in wood preservative formulations. The process involves reacting a trialkylamine with an alkyl bromide to form a quaternary tetraalkylammonium bromide salt, converting the quaternary tetraalkylammonium bromide salt to a quaternary tetraalkylammonium hydroxide salt by using an ion exchange resin, and converting the quaternary tetraalkylammonium hydroxide salt to the quaternary tetraalkylammonium salt of the selected anion.
专利号:US-9129720-B2 优先权日:2007-04-13 标题:Synthesis of uniform nanoparticle shapes with high selectivity 发明人:ASOKAN SUBASHINI; WONG MICHAEL SHA-NANG 权利人:UNIV RICE WILLIAM M 摘要:This invention provides non-spherical nanoparticle compositions that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.
专利号:US-9790531-B2 优先权日:2012-08-14 标 题 :Enzymes and polymerases for the synthesis of RNA 发明人:WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN 权利人:MODERNATX INC 摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.
专利号:US-7153933-B2 优先权日:2001-12-07 标 题 :Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same 发明人:WU SHIH-KWANG; CHANG TING-GUNG; TSENG CHIN-LU; CHEN LI-JUNG; SHIH KAE-SHYANG 权利人:DEV CENTER BIOTECHNOLOGY 摘要:A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and lipid, wherein the spacer may comprise PEG. Several advantages can be achieved, such as the synthetic procedure can be simplified, the synthesis process can be set to automation, the purification is easier in each reaction step, and the product losses can be reduced to minimal during synthesis. The present synthesis method is suitable for preparing a wide range of peptide-spacer-lipid conjugates, provides a peptide-spacer-lipid conjugate prepared by the solid phase synthesis method of the present invention, which can be incorporated into a liposome as the targeting moiety for liposomal drug delivery to specific cells, and provides a targeting liposome containing the present peptide-spacer-lipid conjugate.
专利号:WO-9925385-A1 优先权日:1997-11-17 标 题:A method of increasing nucleic acid synthesis with ultrasound 发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID 权利人:IMARX PHARMACEUTICAL CORP 摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
专利号:US-2018312534-A1 优先权日:2015-10-16 标题:Fluorescent anticancer platinum drugs 发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA 权利人:INVICTUS ONCOLOGY PVT LTD 摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.
摘要:Yoshimoto, F. K.; Li, Q., Science of Synthesis Knowledge Updates, (2012) 1, 250. 摘要:Camp, J. E., Science of Synthesis Knowledge Updates, (2012) 1, 338. 参考文献:10.1007/112_2018_11 摘要:Momtazi-Borojeni AA, Mosafer J, Nikfar B, Ekhlasi-Hundrieser M, Chaichian S, Mehdizadehkashi A, Vaezi A. Curcumin in Advancing Treatment for Gynecological Cancers with Developed Drug- and Radiotherapy-Associated Resistance. Rev Physiol Biochem Pharmacol. 2019;176():107–29. doi: 10.1007/112_2018_11.