CAS: 219861-08-2; Escitalopram Oxalate

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CAS号144-62-7 草酸 | CAS号128196-01-0 艾司西酞普兰 | CAS号50-00-0 甲醛 | CAS号488787-59-3 (S)-4-[4-(二甲胺基)... | CAS号1073819-95-0 (S)-citalopram ... | CAS号103146-25-4 4-(4-(二甲基氨基)-1-... | CAS号460-00-4 对氟溴苯 | CAS号352-13-6 4-氟苯基溴化镁 | CAS号5407-04-5 3-二甲氨基氯丙烷盐酸盐 | CAS号19070-16-7 magnesium,N,N-d... | CAS号128196-01-0 艾司西酞普兰

依他普仑置于草酸体系中,用 乙醇 用作溶剂,化学反应 10.5H,反应生成草酸右旋西酞普兰
参考文献:Process For Resolving Citalopram Via Its (S)-Enriched Citalopram Tartrate Compound.
标题:Process For Resolving Citalopram Via Its (S)-Enriched Citalopram Tartrate Compound.

专利信息

专利号:US-2006030625-A1
优先权日:2004-08-06
标 题 :Dietary neurotransmitter precursors for balanced synthesis of neurotransmitters
发明人：HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
权利人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
摘要:Dietary supplements for treating a neurotransmitter deficiency include one or more precursors of the deficient neurotransmitter and a cofactor for activating in vivo enzymatic synthesis of the deficient neurotransmitter. The dietary supplements can also include an appropriate neurotransmitter, such as an amino acid. When administered through the oral mucosa, increases in levels of the deficient neurotransmitters and relief from deficiency symptoms are obtained.

专利号:US-2008199922-A1
优先权日:2005-06-22
标题 :Chemoenzymatic Process for the Synthesis of Escitalopram
发明人：COTTICELLI GIOVANNI; SALVETTI RAUL; BERTONI CHIARA
权利人:ADORKEM TECHNOLOGY SPA
摘要:A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C 1 -C 4 alkyl residue or an aryl residue under the action of an esterase from Aspergillus niger.

专利号:US-8815883-B2
优先权日:2009-11-02
标 题 :Compounds and methods for inhibiting serotonin synthesis
发明人：LANDRY DONALD; DENG SHI-XIAN
权利人:LANDRY DONALD; DENG SHI-XIAN; TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK
摘要:Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis.

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人：TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:US-6010861-A
优先权日:1994-08-03
标题:Target specific screens and their use for discovering small organic molecular pharmacophores
发明人：BLUME ARTHUR J
权利人:DGI BIOTECHNOLOGIES LLC
摘要:The invention relates to a general process by which recombinantly derived variable domains of antibodies encompassing either or both light and heavy variable regions with or without respective constant regions are engineered and selected for identification of unique surface domains of pharmaceutical targets or parts thereof which regulate target function. The recombinant antibodies are useful as reagents for high volume, rapid screening of occupation of the active surface domains by natural or synthetic entities. This invention is also directed to elucidating the three dimensional conformation of the antibodies, or parts thereof, which bind to the pharmaceutical targets and confers activity. Methods for creating high resolution molecular models which can direct the synthesis of biologically active small organic molecules useful as viable discovery drug leads are also provided.

专利号:US-9359376-B2
优先权日:2011-04-08
标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.