CAS: 21423-81-4; 3-Chloro-4-Methylbenzonitrile

上下游产品

CAS号67952-93-6 3-氯-4-甲基苄胺 | CAS号143-33-9 氰化钠 | CAS号95-74-9 3-氯对甲苯胺 | CAS号5162-82-3 3-氯-4-甲基苯甲酸 | CAS号21924-83-4 4-溴甲基-3-氯苯腈 | CAS号25539-20-2 2-苯氧基对苯二甲酸 | CAS号24377-95-5 3-氯-4-甲基苯甲酰胺 | CAS号67952-93-6 3-氯-4-甲基苄胺 | CAS号3411-03-8 3-氯-4-甲基苯甲醛 | CAS号106269-39-0 9-oxoxanthene-3... | CAS号863868-32-0 4-甲基-3-(4,4,5,5... | CAS号500024-78-2 (Z)-3-氯-N-羟基-4-甲基苯脒 | CAS号58588-64-0 3-氯-4-甲酰基苯甲腈

3-Chloro-4-Methyl-N,N-Dichlorobenzylamine置于三乙胺体系中,用 二氯甲烷 用作溶剂,以89%的收率获得3-氯-4-甲基苯甲腈
参考文献:The N-Chlorination Of Primary Amines Using Fecl3 And M-Cpba
标题:The N-Chlorination Of Primary Amines Using Fecl3 And M-Cpba
摘要:采用m-Cpba作为氧化剂,Fecl3作为氯源,在0oc下成功实施了一种从伯胺合成n,N-二氯胺的简单有效方法.此外,N,N-二氯胺能够以非常好产率转化为腈类或n-氯亚胺.
Doi:10.1246/cl.130883

专利信息

专利号:US-7951827-B2
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
发明人：TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A
权利人:UNIV NORTH CAROLINA
摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

专利号:US-7569606-B2
优先权日:2006-01-26
标 题 :Platinum complexes with mononitrile-containing ligands
发明人：XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:EA-014940-B1
优先权日:2005-08-25
标题 :Condensed Derivatives of Imidazole to Inhibit Aldosterone Synthesis and Aromatics

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof