CAS: 17432-38-1; Pentamethylbenzaldehyde

该化合物是一种替代苯甲二烯衍生物,其特征为附于苯环的五甲基组,这种结构改变增强了其消毒和电子特性,使其成为有机合成中有价值的中间体;由于甲基组的电子施食效应,该化合物在诸如阿道尔凝聚和增生 Grignard等反应中表现出了更大的稳定性和选择性;其高纯度和定义明确的再活性简介使其适合用于药物,农用化学品和高级材料合成.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

pentamethylbenzene, Hexamethylbenzene Methyl-[1-pentamethylphenyl-meth-(Z)-ylidene]-amine tert-Butyl-[1-pentamethylphenyl-meth-(E)-ylidene]-aminepentamethylbenzoic acid 17H27N°C17H27NO Adamantan-1-yl-[1-pentamethylphenyl-meth-(E)-ylidene]-amine tert-Butyl-[1-pentamethylphenyl-meth-(E)-ylidene]-amine

合成工艺路线路线简述

    📜五甲基苯置于三氯化铝 盐酸体系中,用 (2S)-N-Methyl-1-Phenylpropan-2-Amine Hydrate,氯苯 用作溶剂,以73.8%的收率获得五甲基苯甲醛
    参考文献:Process For Preparing A Methyl-Substituted Benzaldehyde
    标题:Process For Preparing A Methyl-Substituted Benzaldehyde
    摘要:使用一氧化碳和氯化氢,在铝氯催化剂的存在下,通过在包括氯苯作用作溶剂的反应混合物中,对烷基取代苯甲醛进行甲酰化的过程,以及在包括环己酮作为还原剂的反应混合物中,在自氧化引发剂的存在下,对烷基取代苯甲醛进行氧化的过程.

    海关参考信息

    专利信息


    专利号:US-4033949-A
    优先权日:1976-04-14
    标 题:Analogs of thromboxane B2 and processes for their synthesis
    发明人:KELLY ROBERT C; NELSON NORMAN A
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.

    专利号:US-6211329-B1
    优先权日:1997-06-26
    标题:Process for preparation of a dendritic polyol
    发明人:REHNBERG NICOLA; PETTERSSON BO; ANNBY ULF; MALMBERG MATS
    权利人:PERSTORP AB
    摘要:A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of which two are hydroxyl groups. The two hydroxyl groups of the ranching chain extender is acetal protected by reaction between said two hydroxyl groups and an acetal-forming carbonyl compound, preferably an aldehyde. The acetal protected branching chain extender is then employed for addition to the initiator molecule of a first branching generation followed by an optional deprotection of the hydroxyl groups by decomposition of acetals and for addition in repeated steps of further branching generations. Additions of branching generations individually employ an acetal protected branching chain extender synthesized from the same or a different branching chain extender and/or acetal-forming carbonyl compound and addition of a branching generation is optionally followed by addition of a spacing generation.

    专利号:US-4070384-A
    优先权日:1976-04-14
    标 题 :Process for preparing thromboxane B compounds from prostaglandin fα co
    发明人:SCHNEIDER WILLIAM P
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-lla-oxa-PGF 2 α). These analogs are particularly and especially useful as reproductive cycle control agents.

    专利号:US-4052552-A
    优先权日:1976-08-20
    标 题:Thromboxane b analogs
    发明人:SCHNEIDER WILLIAM P
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 α). These analogs are particularly and especially useful as reproductive cycle control agents.

    专利号:US-4054737-A
    优先权日:1976-08-20
    标 题 :Thromboxane B analogs
    发明人:KELLY ROBERT C; NELSON NORMAN A
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 α). These analogs are particularly and especially useful as reproductive cycle control agents.

    专利号:US-4107427-A
    优先权日:1976-08-20
    标题 :Process and intermediates for preparing Thromboxane B1
    发明人:KELLY ROBERT C
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B2 (11 beta -homo-11a-oxa-PGF2 alpha ). These analogs are particularly and especially useful as reproductive cycle control agents.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1055/a-1739-4793
    摘要:Sekine K, Kuninobu Y, Shiozuka A. Photoinduced Organic Reactions by Employing Pyrene Catalysts. Synthesis. 2022 Feb 25;54(10):2330–9. doi: 10.1055/a-1739-4793.
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