CAS: 136191-16-7; 4-Fluoro-7-Hydroxy-2,3-Dihydro-1H-Inden-1-One

相似化合物

1092347-76-6 1260013-93-1 1092347-77-7

上下游产品

CAS号127033-13-0 4-氟-7-甲氧基-2,3-二...

4-Fluorophenyl Acrylate 反应生成4-氟-7-羟基-1-茚酮
参考文献:Morpholine Derivative
标题:Morpholine Derivative
摘要:一种由公式(i)表示的吗啡啶衍生物或其药学上可接受的盐:##str1##其中r.Sup.1和r.Sup.3,可以相同也可以不同,分别代表氢原子或较低的烷基;R.Sup.2代表卤素原子;虚线表示可选的双键.这些化合物表现出选择性的5-Ht再摄取抑制活性和选择性的5-Ht.Sub.2受体拮抗活性,可用作治疗抑郁症,焦虑等疾病的治疗药物,副作用较小.

专利信息

专利号:WO-2024159288-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting amides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting amides. More specifically, the present invention relates to amides comprising formula (I): (Ia) (Ib), in which the substituents R1 to R27 are selected independently of the groups defined in the description, as well as to processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.