CAS: 118396-02-4; (1R,2R,3R,7S,7Ar)-3-(Hydroxymethyl)Hexahydro-1H-Pyrrolizine-1,2,7-Triol

该化合物是一种自然形成的多氢氧酸盐,主要与卡斯塔诺斯珀穆姆植物分离,主要与这些植物分离;承认澳洲素是针对甘蓝酶,特别是α-甘蓝菌的强烈抑制性活动,使其成为生物化学和药理研究的宝贵化合物;澳洲独特的结构特征有助于其高度特性和紧密结合,有助于对碳水化合物新陈代谢和酶机制进行详细研究;其稳定性和特性完善性能便于将其用作分析应用的参考标准;研究人员重视澳洲素,因为它有能力解释与甘蓝相关的途径及其开发代谢紊乱治疗剂的潜力.

英文名称(1R,2R,3R,7S,7Ar)-3-(Hydroxymethyl)Hexahydro-1H-Pyrrolizine-1,2,7-Triol
中文名称(1R,2R,3R,7S,7aR)-3-(羟甲基)六氢-1H-吡咯嗪-1,2,7-三醇
IUPAC名称(1R,2R,3R,7S,7aR)-3-(hydroxymethyl)hexahydro-1H-pyrrolizine-1,2,7-triol
其它别名Hexahydro-3-(Hydroxymethyl)-1H-Pyrrolizine-1,2,7-Triol; Australine Hcl; Australine Hydrochloride; Australine, Hydrochloride, Castanospermum Australe; (1R,2R,3R,7S,7Ar)-3-Hydroxymethyl-1,2,7-Trihydroxypyrrolizidine Hcl; (1R,2R,3R,7S,7Ar)-3-Hydroxymethyl-1,2,7-Trihydroxypyrrolizidine, Hydrochloride; 1H-Pyrrolizine-1,2,7-Triol, Hexahydro-3-(Hydroxymethyl)-, (1R,2R,3R,7S,7Ar)-; Australine Hydrobromide
CAS编号118396-02-4
MFCD编号:MFCD00272577
分子式:C8H15NO4分子量:189.21
产品CID: 235256
产品分类有机原料→分子砌块→脂肪杂环类化合物→吡咯烷类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: AIQMLBKBQCVDEY-OZRXBMAMSA-N
InChI=1S/C8H15NO4/c10-3-4-7(12)8(13)6-5(11)1-2-9(4)6/h4-8,10-13H,1-3H2/t4-,5+,6-,7-,8-/m1/s1
计算化学: 氢键受体数5.0氢键供体数4.0可旋转键数1.0

相似化合物

2927440-48-8 34610-36-1 63121-26-6

MSDS等安全信息

上下游产品

栗精胺 (1S,6S,7R,8R,8Ar)-2,6,7,8-Tetrahydroxy-Indolizidine 79831-76-8
(1R,2R,3R,7S,7Ar)-3-(Tert-Butoxymethyl)Hexahydro-1H-Pyrrolizine-1,2,7-Triol 923592-17-0
(1R,2R,3R,7S,7Ar)-1,2-Dibenzyloxy-3-Benzyloxymethyl-7-Hydroxy-2,3,5,6,7,7A-Hexahydro-1H-Pyrrolizine 301310-42-9
(1R,2R,3R,7S,7Ar)-1,2,7-Tris(Benzyloxy)-3-(Tert-Butoxymethyl)Hexahydro-1H-Pyrrolizine 923592-16-9

合成工艺路线路线简述

📜N-[(2S,3S,4R,5S)-4,5,6-Trihydroxy-6-(Hydroxymethyl)-2-Prop-2-Enyloxan-3-Yl]Formamide置于臭氧,盐酸,Sodium Acetate,Sodium Cyanoborohydride,溶剂黄146体系中,用甲醇,1,4-二氧六环,水用作溶剂,化学反应 108.0H,反应生成六氢-3-(羟甲基)-1H-吡咯里嗪-1,2,7-三醇
参考文献:化学-酶法合成3-Epiaustraline,Australine和7-Epialexine.
标题:化学-酶法合成3-Epiaustraline,Australine和7-Epialexine.
摘要:顺序的酶醛醇缩醛反应和双还原胺化反应可合成四羟基吡咯烷核生物碱,3-表氨司他林(14),奥曲林(1)和7-表艾利辛(11).该方法允许它们的快速构建,而无需保护羟基官能团的基团操纵.另外,描述了改进的二乙烯基甲醇(3)不对称环氧化的方法,并将该产物用于所需三醇7和ent-7的简明合成中.
Doi:10.1021/jo000933D

海关参考信息

2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2006008493-A1
优先权日:2004-07-23
标题 :Synthesis of polyhydroxylated alkaloids
发明人：NASH ROBERT JAMES; FLEET GEORGE WILLIAM JOHN; VAN AMEIJDE JEROEN; HORNE GRAEME
权利人:MNL PHARMA LTD; NASH ROBERT JAMES; FLEET GEORGE WILLIAM JOHN; VAN AMEIJDE JEROEN; HORNE GRAEME
摘要:A process for the production of a polyhydroxylated bicyclic (e.g. pyrrolizidine such as casuarine (10), indolizidine or quinolizidine) alkaloid comprises the cyclisation of a pyrrolidine or piperidine intermediate having three or more free hydroxyl groups.

专利号:EP-4376865-A2
优先权日:2021-07-26
标题 :Pulse protein-based composition for activating the synthesis of fgf19

专利号:WO-2023006248-A2
优先权日:2021-07-26
标题 :Method for activating the synthesis of fgf19

专利号:US-2010248365-A1
优先权日:2009-03-27
标题:Ganglioside biosynthesis modulators
发明人：CRAWFORD BRETT E; GLASS CHARLES A; BROWN JILLIAN R; BAI XIAOMEI
权利人:ZACHARON PHARMACEUTICALS INC
摘要:Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.