CAS: 115-56-0; 5-Ethyl-5-(2-Methylprop-2-Enyl)-2-Sulfanylidene-1,3-Diazinane-4,6-Dione

该化合物是一种含有硫的环环化合物,其核心结构为火利米丁-二酮,其独特的分子框架以乙基和二甲基丙基-2-en-1-yl替代成分为特征,有助于其在有机合成和药用化学中的回作用和潜在应用; 硫基(-SH)组的存在增强了其作为核分裂剂或离子体在金属协调化学中的效用; 该化合物可作为开发药用活性分子或功能材料的多种中间体; 其结构特征表明有可能进一步衍生,对热循环化学和药物发现的研究具有价值.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号56640-39-2 Propanedioic ac...

合成工艺路线路线简述

  • 合成目标产物 5-Ethyldihydro-5-(2-Methylallyl)-2-Thioxo-1H,5H-Pyrimidine-4,6-Dione 主要起始原料 Nsc44906
  • (文献来源)合成步骤主要原料 Nsc44906
📜Ethyl-(2-Methyl-Allyl)-Malonic Acid Diethyl Ester置于sodium Ethanolate,尿素体系中,化学反应生成美沙拉妥
参考文献:Sulfur-Containing Barbiturate Hypnotics
标题:Sulfur-Containing Barbiturate Hypnotics
摘要:
Doi:10.1021/ja01313A062

海关参考信息

专利信息


专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:US-11759496-B2
优先权日:2016-05-10
标题:Compounds and pharmaceutical use thereof in the treatment of cancer
发明人:SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
权利人:KAROYAN PHILIPPE
摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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