CAS: 98977-36-7; 1-Boc-3-Piperidinone

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N-Boc-3-羟基哌啶置于2,2,6,6-四甲基哌啶氧化物,碘苯二乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 N-叔丁氧羰基-3-哌啶酮
参考文献:醇通过氧化/亚胺-亚胺形成/还原胺化反应反应生成的无金属,轻度,非四聚体,化学和对映体或对映体或非对映体选择性n-烷基化:实用合成八氢吡喃并吡啶并吲哚和更高环的类似物
标题:醇通过氧化/亚胺-亚胺形成/还原胺化反应反应生成的无金属,轻度,非四聚体,化学和对映体或对映体或非对映体选择性n-烷基化:实用合成八氢吡喃并吡啶并吲哚和更高环的类似物
摘要:通过在dmpu中使用tempo-Baib-Heh-Brønsted酸催化作作为反应溶剂和化学计量的胺,通过氧化/亚胺-亚胺形成/还原级联反应,开发了一种温和的步骤以及原子经济的非三聚化学和对映选择性n-烷基化方法.优化的条件进一步扩展为使用vapol衍生的磷酸(vapol-Pa)作为布朗斯台德酸催化剂在非酶原位氢转移条件下形成的手性胺的非酶动力学拆分.所呈现的反应的对映选择性级联被成功地用于在octahydropyrazinopyridoindole的合成和其较高的环类似物.
DOI:10.1021/jo4012249

专利信息

专利号:US-6069245-A
优先权日:1996-04-17
标 题:Asymmetric synthesis of azepines
发明人：MATZINGER PETER KARL; SCALONE MICHELANGELO; ZUTTER ULRICH
权利人:HOFFMANN LA ROCHE
摘要:A novel process for the manufacture of compounds of the formula ##STR1## wherein R 1 and R 2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of formula I.

专利号:US-2015031675-A1
优先权日:2012-02-02
标题 :Diazabicyclo[3.3.1]nonanes, methods of synthesis, and uses thereof
发明人：STRACHAN JON-PAUL; YOHANNES DANIEL
权利人:TARGACEPT INC
摘要:The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).

专利号:CN-114717211-B
优先权日:2022-03-23
标 题:Imine reductase mutant M5 and its application in the synthesis of nitrogen heterocyclic chiral amines

专利号:US-5902882-A
优先权日:1996-04-17
标 题 :Assymetric synthesis of azepines

专利号:US-9056876-B2
优先权日:2011-09-16
标 题:Substituted 1H-pyrazolo[3′,4′,4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：CONN JEFFREY P; LINDSLEY CRAIG W; WOOD MICHAEL R; HOPKINS COREY R; SALOVICH JAMES M; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 1H-pyrazolo[3′,4′:4,5]thieno[2,3-b]pyridin-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-6914140-B1
优先权日:1996-04-17
标题:Asymmetric synthesis process
发明人：MATZINGER PETER KARL; SCALONE MICHELANGELO; ZUTTER ULRICH
权利人:HOFFMANN LA ROCHE
摘要:A novel process for the manufacture of compounds of the formula n n nwherein R 1 and R 2 independently represent aroyl.n n The present invention also concerns novel intermediates used in the novel process for making compounds of formula I.