CAS: 930-46-1; (1R,2R)-Cyclopentane-1,2-Diol

该化合物是一种双环有机化合物,其特点是与环球环形环形相连的两组氢氧基(-OH)组,这种复合物具有气质,有1R,2202 # 272702 # 注解,表明其替代体的空间安排;在室内温度下,它无色可粉黄液,由于氢氧基体的极性,在水中溶解;该化合物经常用于有机合成,并且作为制作各种药品和农用化学物的手工业建筑块;它的独特结构允许氢结合,有助于其溶解性和再活性;此外,(1R,2R)-转1,2环球-开坦尼醇可以参与各种化学反应,包括氧化和化,使其成为合成化学的多用途中间体;应当参考安全数据,以便处理,如同任何化学物质一样,确保采取适当的预防措施.

英文名称(1R,2R)-Cyclopentane-1,2-Diol
中文名称(1R,2R)-环戊烷-1,2-二醇
IUPAC名称(1R,2R)-cyclopentane-1,2-diol
其它别名(1R,2R)-(-)-Trans-1,2-Cyclopentanediol; (1R,2R)-Trans-1,2-Cyclopentanediol; (1R)-Trans-1,2-Cyclopentanediol; (1R,2R)-1,2-Cyclopentanediol; 1,2-Cyclopentanediol, (1R,2R)-
CAS编号930-46-1
MFCD编号:MFCD00082580
EINECS号:829-081-8
分子式:C5H10O2分子量:102.13
产品CID: 1969286
产品分类有机原料→分子砌块→脂肪环类化合物→环戊烷类化合物

相似结构搜索
InChIKey: VCVOSERVUCJNPR-RFZPGFLSSA-N
InChI=1S/C5H10O2/c6-4-2-1-3-5(4)7/h4-7H,1-3H2/t4-,5-/m1/s1
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数*

相似化合物

5057-99-8 5057-98-7 63261-45-0

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明22-24/25
WGK Germany3

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

285-67-6 = 930-46-1
反应条件:1.1 Reagents: Water Catalysts: Epoxide Hydrolase Solvents: Water,1-Butyl-3-Methylimidazolium Hexafluorophosphate; 48 H,37 °C
标题:Effect Of Ionic Liquids On Epoxide Hydrolase-Catalyzed Synthesis Of Chiral 1,2-Diols
作者:Chiappe,Cinzia; Leandri,Elsa; Hammock,Bruce D.; Morisseau,Christophe
参考文献:Green Chemistry 日期:2007 卷标:9(2) 页码:162-168]

285-67-6 = 930-46-1
反应条件:1.1 Catalysts: Epoxide Hydrolase Solvents: Water
标题:Enantioselective Cascade Biocatalysis Via Epoxide Hydrolysis And Alcohol Oxidation: One-Pot Synthesis Of (R)-α-Hydroxy Ketones From Meso- Or Racemic Epoxides
作者:Zhang,Jiandong; Wu,Shuke; Wu,Jinchuan; Li,Zhi
参考文献:Acs Catalysis 日期:2015 卷标:5(1) 页码:51-58]

285-67-6 = 930-46-1
反应条件:1.1 Catalysts: Epoxide Hydrolase,Hydrolase,Epoxide (Sphingomonas Strain Hxn-200) Solvents: Hexane,Water; 360 Min,Ph 7.5,30 °C
标题:Enantioselective Hydrolysis Of Racemic And Meso-Epoxides With Recombinant Escherichia Coli Expressing Epoxide Hydrolase From Sphingomonas Sp. Hxn-200: Preparation Of Epoxides And Vicinal Diols In High Ee And High Concentration
作者:Wu,Shuke; Li,Aitao; Chin,Yit Siang; Li,Zhi
参考文献:Acs Catalysis 日期:2013 卷标:3(4) 页码:752-759]

241147-33-1 = 930-46-1
反应条件:1.1 Reagents: (+/-)-α-Pinene,Bis[(1R,2S,3R,5R)-2,6,6-Trimethylbicyclo[3.1.1]Hept-3-Yl]Borane Solvents: Tetrahydrofuran1.2 Reagents: Acetaldehyde1.3 Reagents: Sodium Hydroxide Solvents: Water1.4 Reagents: Hydrogen Peroxide Solvents: Water1.5 Reagents: Potassium Carbonate
标题:Chiral Synthesis Via Organoboranes. 45. Asymmetric Hydroboration Of 1-Cyclopentenol Derivatives Using Diisopinocampheylborane. Synthesis Of Optically Active Cyclopentane-1,2-Diol Derivatives Of High Optical Purity
作者:Brown,Herbert C.; Murali,Dhanabalan; Singaram,Bakthan
参考文献:Journal Of Organometallic Chemistry 日期:1999 卷标:581(1-2) 页码:116-121]

= 930-46-1 [标题:Reaction Conditions
标题:Crystalline Stereocomplexed Polycarbonates: Hydrogen-Bond-Driven Interlocked Orderly Assembly Of The Opposite Enantiomers
作者:Liu,Ye; Ren,Wei-Min; Wang,Meng; Liu,Chuang; Lu,Xiao-Bing
参考文献:Angewandte Chemie 日期:2015 卷标:54(7) 页码:2241-2244]

285-67-6 = 930-46-1
反应条件:1.1 Reagents: Water Catalysts: Limonene-1,2-Epoxide Hydrolase Solvents: Acetonitrile,Water; 10 H,Ph 7.4,30 °C
标题:Manipulating The Stereoselectivity Of Limonene Epoxide Hydrolase By Directed Evolution Based On Iterative Saturation Mutagenesis
作者:Zheng,Huabao; Reetz,Manfred T.
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(44) 页码:15744-15751]

= 930-46-1 [标题:Reaction Conditions
标题:A Preparative Method For Kinetic Resolution Of Trans-1,2-Cycloalkanediols Through Lipase-Catalyzed Transesterification
作者:Kaga,Harumi; Yamauchi,Yukio; Narumi,Atsushi; Yokota,Kazuaki; Kakuchi,Toyoji
参考文献:Enantiomer 日期:1998 卷标:3(2) 页码:203-205]

= 930-46-1 [标题:Reaction Conditions
标题:Enzymic Hydrolysis And Esterification. Routes To Optically Pure Cyclopentanols
作者:Seemayer,R.; Schneider,M. P.
参考文献:Recueil Des Travaux Chimiques Des Pays-Bas 日期:1991 卷标:110(05) 页码:171-4]

113350-85-9 = 930-46-1
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol
标题:An Efficient Synthesis Of Both Enantiomers Of Trans-1,2-Cyclopentanediol And Their Conversion To Two Novel Bidentate Phosphite And Fluorophosphinite Ligands
作者:Cunningham,Allan F. Jr.; Kuendig,E. Peter
参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(8) 页码:1823-5]

= 930-46-1
反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Formic Acid
标题:Alicyclic Glycols. Vi. Derivatives Of 1,2-Cyclopentanediol
作者:Owen,L. N.; Smith,Peter N.
参考文献:Journal Of The Chemical Society 日期:1952 卷标:4026 页码:4026-35]

285-67-6 = 930-46-1
反应条件:1.1 Reagents: Water Catalysts: 2,2′-[(1S,2S)-1,2-Cyclohexanediylbis(Nitrilomethylidyne)]Bis[4,6-Bis(1,1-Dimethy...
标题:The Catalytic Activity Of New Chiral Salen Complexes Immobilized On Mcm-41 In The Asymmetric Hydrolysis Of Epoxides To Diols
作者:Kim,G.-J.; Park,D.-W.
参考文献:Catalysis Today 日期:2000 卷标:63(2-4) 页码:537-547]

26620-22-4 = 930-46-1 + 133442-59-8 + 105663-22-7
反应条件:1.1 Catalysts: Triacylglycerol Lipase Solvents: Water
标题:Development Of The Enabling Route For Glecaprevir Via Ring-Closing Metathesis
作者:Cink,Russell D.; Lukin,Kirill A.; Bishop,Richard D.; Zhao,Gang; Pelc,Matthew J.; Et Al
参考文献:Organic Process Research & Development 日期:2020 卷标:24(2) 页码:183-200]

= 930-46-1
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water
标题:Microstructure Analysis Of Poly(Cyclopentene Carbonate)S At The Diad Level
作者:Liu,Ye; Li,Rong-Rong; Lu,Xiao-Bing
参考文献:Macromolecules (Washington 日期:2015 卷标:48(19) 页码:6941-6947]

285-67-6 = 930-46-1
反应条件:1.1 Solvents: Ethanol,Water; Ph 7.5,30 °C
标题:Enzymic Production Of Optically Active Epoxides And Vicinal Diols From Meso-Epoxides Using Yeast Epoxide Hydratase
参考文献:World Intellectual Property Organization]

285-67-6 = 930-46-1
反应条件:1.1 Catalysts: Epoxide Hydrolase Solvents: Acetonitrile,Water; 12 - 24 H,Ph 7.5,37 °C
标题:Cloning And Sequences Of Epoxide Hydrolases From Environmental Microorganisms,And Their Use For Enantiomeric Hydrolysis Of Epoxides And Arene Oxides
参考文献:World Intellectual Property Organization]

285-67-6 = 930-46-1
反应条件:1.1 Catalysts: Epoxide Hydrolase
标题:Epoxide Hydrolase-Catalyzed Enantioselective Synthesis Of Chiral 1,2-Diols Via Desymmetrization Of Meso-Epoxides
作者:Zhao,Lishan; Han,Bin; Huang,Zilin; Miller,Mark; Huang,Hongjun; Et Al
参考文献:Journal Of The American Chemical Society 日期:2004 卷标:126(36) 页码:11156-11157]

285-67-6 = 930-46-1
反应条件:1.1 Catalysts: Epoxide Hydrolase
标题:Product Enantioselectivity Of The Microsomal And Cytosolic Epoxide Hydrolase Catalyzed Hydrolysis Of Meso Epoxides
作者:Bellucci,Giuseppe; Capitani,Isabella; Chiappe,Cinzia; Marioni,Franco
参考文献:Journal Of The Chemical Society 日期:1989 卷标:(16) 页码:1170-1]

= 930-46-1 [标题:Reaction Conditions
标题:Asymmetric Conjugate Addition Of Organometallic Reagents To Chiral α,β-Unsaturated Esters
作者:Fang,Chenglin; Ogawa,Tomoyuki; Suemune,Hiroshi; Sakai,Kiyoshi
参考文献:Tetrahedron: Asymmetry 日期:1991 卷标:2(5) 页码:389-98]

51075-28-6 + 5057-99-8 = 930-46-1 + 1448438-48-9
反应条件:1.1 Reagents: Proton Sponge Catalysts: 4-(Dimethylamino)Benzoic Acid,4H,6H-Indeno[2,1-B][1,2,4]Triazolo[4,3-D][1,4]Oxazinium,5A,10B-Dihydro-9-Nitro-... Solvents: Chloroform; 10 Min,Rt; Rt -> 0 °C1.2 18 H,0 °C
标题:Enhanced Rate And Selectivity By Carboxylate Salt As A Basic Cocatalyst In Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation Of Secondary Alcohols
作者:Kuwano,Satoru; Harada,Shingo; Kang,Bubwoong; Oriez,Raphael; Yamaoka,Yousuke; Et Al
参考文献:Journal Of The American Chemical Society 日期:2013 卷标:135(31) 页码:11485-11488]

= 930-46-1 + 5057-98-7
反应条件:1.1 Reagents: Selenium Dioxide,Hydrogen Peroxide Solvents: Tert-Butanol
标题:Alkaloid Syntheses. Ii. The Synthesis Of Glutaraldehyde
作者:Stoll,A.; Lindenmann,A.; Jucker,E.
参考文献:Helvetica Chimica Acta 日期:1953 卷标:36 页码:268-74