CAS: 87952-98-5; Mespirenone
该化合物是一种具有显著药理特性的抗血清化合物,主要因其作为甲虫酮敌国的潜力而受到调查.其分子结构允许选择性地约束矿物类受体,使其成为管理甲虫酮衰竭(如高血压和心脏衰竭)相关条件的候选体.该化合物显示出一种有利的药理动能特征,包括代谢稳定性和降低与早先的抗血清对抗者相比的非目标影响风险.研究表明它可以提供更好的治疗效果,并产生最小的副作用,如超血压或荷尔蒙不平衡. 甲虫素的行动和选择性机制强调了它作为心血管和肾脏治疗中目标的媒介的潜力.
- 英文名称Mespirenone
- 中文名称美螺利酮
- IUPAC名称7alpha-Acetylthio-15beta,16beta-methylen-3-oxo-1,4-pregnadien-21,17beta-carbolacton
- 其它别名Mespirenone; (7a,15a,16a,17a)-7-(Acetylthio)-15,16-dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-1,4,15-triene-21-carboxylic Acid -Lactone; (17S)-7α-(Acetylthio)-15α,16α-dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-1,4,15-triene-21-carboxylic acid γ-lactone; 15alpha,16alpha-Dihydro-17-hydroxy-7alpha-mercapto-3-oxo-3'H-cyclopropa(15,16)-17alpha-pregna-1,4,15-triene-21-carboxylic acid, gamma-lactone, acetate; 7alpha-Acetylthio-15beta,16beta-methylen-3-oxo-1,4-pregnadien-21,17beta-carbolacton; Mespirenona; Mespirenona [spanish]
- CAS编号87952-98-5
- MFCD编号:MFCD00867340
- FDA UNII编号:E91TME2I23
- 分子式:C25H30O4S分子量:426.57
- 产品CID: 1888616
- 产品分类原料药 → 激素及调节内分泌功能类药 → 雄激素及同化激素类药
物理性质
MSDS等安全信息
上下游产品
7α-(acetylthio)-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone 15β,16β-methylene-3-oxo-17α-pregna-4,6-diene-21,17-carbolactone 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one (3S,5R,8R,9S,10R,13S,14S,15S,16S,17S)-17-(3-Hydroxy-propyl)-10,13-dimethyl-1,3,4,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-2H-cyclopropa[15,16]cyclopenta[a]phenanthrene-3,5,17-triol合成工艺路线路线简述
📜6,7-去亚甲基-6,7-去氢屈螺酮置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 甲醇,水,苯 作为反应溶剂,化学反应 42.0H,反应生成 美螺利酮
参考文献:Aldosterone Antagonists. 2. New 7.Alpha.-(Acetylthio)-15,16-Methylene Spirolactones
标题:Aldosterone Antagonists. 2. New 7.Alpha.-(Acetylthio)-15,16-Methylene Spirolactones
摘要:Some 15,16-Methylene Derivatives Of The Aldosterone Antagonist Spironolactone Were Synthesized With The Purpose Of Increasing The Antialdosterone Potency And Reducing The Endocrinological Effects Of This Standard Compound. By Introduction Of A 1,2-Double Bond And A 15 Beta,16 Beta-Methylene Ring In The Spironolactone Molecule Both Goals Were Achieved. In Animal Studies Mespirenone Exhibited A Threefold-Greater Antialdosterone Potency And Less Than 10% Of The Antiandrogenic Activity Of Spironolactone.
DOI:10.1021/jm00391A023
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:DE-3718109-A1
优先权日:1987-05-27
标题:METHOD FOR SEPARATING PROCESS PRODUCTS OF MESPIRENON SYNTHESIS
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Opoku J, Kalimi M, Agarwal M, Qureshi D. Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension. Am J Physiol. 1991 Feb;260(2 Pt 1):E269-71. doi: 10.1152/ajpendo.1991.260.2.E269.合成参考文献
参考文献:10.1152/ajpendo.1991.260.2.e269
摘要:Opoku J, Kalimi M, Agarwal M, Qureshi D. Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension. American Journal of Physiology-Endocrinology and Metabolism. 1991 Feb 01;260(2):E269–71. doi: 10.1152/ajpendo.1991.260.2.e269.
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