CAS: 87392-07-2; (S)-Tetrahydrofuran-2-Carboxylic Acid

相似化合物

87392-05-0 16874-33-2 22415-59-4

上下游产品

CAS号97-99-4 四氢糠醇 | CAS号37443-42-8 2-四氢糠酸甲酯 | CAS号16874-33-2 2-四氢呋喃甲酸

2-四氢呋喃甲酸 反应生成 (S)-四氢呋喃-2-甲酸
参考文献:呋尼地平立体异构体的合成,结构和药理评价.
标题:呋尼地平立体异构体的合成,结构和药理评价.
摘要:报道了甲基四氢呋喃-2-基甲基2,6-二甲基-4-(2'-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯(呋喃地平)的四种立体异构体的合成和药理活性.通过改进的hantzsch合成,通过(-)-或(+)-四氢呋喃-2-基甲基3-氨基巴豆酸酯与2-[((2'-硝基苯基)亚甲基]乙酰乙酸甲酯的合成,或通过反应(-)-或(+)-四氢呋喃-2-基甲基2-[((2'-硝基苯基)亚甲基]乙酰乙酸酯和3-氨基巴豆酸甲酯.用聚(d-苯基甘氨酸)作为手性固定相,通过色谱法分离得到的1∶1非对映异构混合物.立体异构体的对映体纯度通过高效液相色谱-手性固定相技术(HPLC-Csp)测定.尝试在不同溶剂中获得单一立体异构体的晶体失败,而由(+/-)-四氢呋喃-2-基甲基2-[((2'-硝基苯基)亚甲基]乙酰乙酸酯和3-氨基巴豆酸甲酯获得的产物的甲醇结晶x射线晶体学证明是最难溶的外消旋体的优质晶体,证明是(ss)/
DOI:10.1021/jm00015A005

专利信息

专利号:US-11840544-B2
优先权日:2018-07-02
标 题 :Intermediates in the synthesis of C3-substituted cephalosporins
发明人：MADELA KAROLINA
权利人:NORBROOK LAB LTD
摘要:Disclosed herein are novel and inventive methods for preparing intermediates in the synthesis of C3-substituted cephalosporins. One preferred C3-substituted cephalosporin of clinical interest is Cefovecin. Accordingly, the present invention provides for methods of preparing reactive halogen intermediates for use in the synthesis of C3-substituted cephalosporins, such as Cefovecin. In the case of Cefovecin the reactive intermediates are of the formula:

专利号:WO-2023286078-A1
优先权日:2021-07-13
标题:An improved process for the preparation of an intermediate of baloxavir morboxil
发明人：TALASANI SHYAM SUNDER REDDY; BUDIDETI SHANKAR REDDY; KOTTE RAJASHEKAR; SATTI VENKATA REDDY; MALA NAGENDRA; MUDDASANI PULLA REDDY; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:The present invention provides an improved process for the preparation of (12aR)-3,4,12,12a-tetrahydro-7-(phenylmethoxy)-1H-[1,4]oxazino[3,4-c] pyrido[2,1-f] [1,2,4]triazine-6,8-dione of Formula (I). Formula I which is a key intermediate in the synthesis of Baloxavir Morboxil of Formula (II).

专利号:US-5710246-A
优先权日:1996-03-19
标题 :Process for intermediates for the synthesis of LHRH antagonists
发明人：FUNK KENNETH W; LUNDELL EDWIN O; MILLER ROBERT B; CHANG JANE L; KISHORE VIMAL; NAPIER JAMES J; STAEGER MICHAEL A
权利人:ABBOTT LAB
摘要:A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

专利号:US-5710247-A
优先权日:1996-03-19
标题:Process and intermediates for the synthesis of LHRH antagonists
发明人：FUNK KENNETH W; LUNDELL EDWIN O; MILLER ROBERT B; CHANG JANE L; KISHORE VIMAL; NAPIER JAMES J; STAEGER MICHAEL A
权利人:ABBOTT LAB
摘要:A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).