CAS: 87121-58-2; 2-(Ethylamino)Isonicotinonitrile

英文名称2-(Ethylamino)Isonicotinonitrile
中文名称2-(乙氨基)异烟腈
IUPAC名称2-(ethylamino)isonicotinonitrile
其它别名2-(Ethylamino)Isonicotinonitrile; 2-(Ethylamino)-4-Pyridinecarbonitrile; 2-(Ethylamino)Pyridine-4-Carbonitrile; 4-Pyridinecarbonitrile, 2-(Ethylamino)-
CAS编号87121-58-2
MFCD编号:MFCD09945910
分子式:C8H9N3分子量:147.18
产品CID: 1876396
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: QJJCFTFAVGJRPR-UHFFFAOYSA-N
InChI=1S/C8H9N3/c1-2-10-8-5-7(6-9)3-4-11-8/h3-5H,2H2,1H3,(H,10,11)
计算化学: 氢键受体数3.0氢键供体数1可旋转键数2

相似化合物

501378-53-6 86649-58-3 1017039-02-9

MSDS等安全信息

上下游产品

2-chloro-4-pyridinenitrile ethylamine

合成工艺路线路线简述

合成目标产物 2-(Ethylamino)Isonicotinonitrile 主要起始原料 2-Chloro-4-Cyanopyridine And Ethylamine
(文献来源)合成步骤主要原料 2-Chloro-4-Cyanopyridine 和 Ethylamine

📜2-氯-4-氰基吡啶,乙胺以四氢呋喃作为反应溶剂,化学反应 3.0H,以49%的收率获得产物2-(乙基氨基)-4-吡啶甲腈
参考文献:Discovery Of An N-(2-Aminopyridin-4-Ylmethyl)Nicotinamide Derivative: A Potent And Orally Bioavailable Ncx Inhibitor
标题:Discovery Of An N-(2-Aminopyridin-4-Ylmethyl)Nicotinamide Derivative: A Potent And Orally Bioavailable Ncx Inhibitor
摘要:Ca2+ Overload In Myocardial Cells Is Responsible For Arrhythmia. Sodium-Calcium Exchanger (Ncx) Inhibitors Are More Effective Than Sodium Hydrogen Exchanger (Nhe) Inhibitors With Regard To Modulation Of Ca2+ Overload,Because Ncx Inhibitors Can Directly Inhibit The Influx Of Ca2+ Into Cells. Ncx Is An Attractive Target For The Treatment Of Heart Failure And Ischemia-Reper-Fusion. We Have Designed And Synthesized A Series Of N-(2-Aminopyridin-4-Ylmethyl)Nicotinamide Derivatives,Based On Compound 5. We Have Discovered A Novel Ncx Inhibitor (23H) With An Ic50 Value Of 0.12 Mu M Against Reverse Ncx. The Inhibitory Activities Of Our Ncx Inhibitors Against Cytochrome P450 Were Also Evaluated. The Effects On Heart Failure And The Pharmacokinetic Profile Of Compound 23H Are Discussed. (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2005.03.052