CAS: 86784-80-7; Corticotropin-Releasing Factor (Human And Rat)

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    专利号:EP-1246837-B1
    优先权日:2000-01-11
    标 题:Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and the use thereof in the synthesis of synthetic proteins and polypeptides
    发明人:AMBLARD MURIEL; MARTINEZ JEAN; BERGE GILBERT
    权利人:CENTRE NAT RECH SCIENT
    摘要:The invention relates to nonpeptide oligomers of amino acids. The oligomers comprise -(NR'-A-CO)-O- units which represent a nonpeptide, restricted-mimetic inducer of the beta turn in a dipeptide or tripeptide fragment. Said oligomers may be produced by peptide synthesis techniques, whether in solution or in the solid phase, and can be used in the synthesis of synthetic proteins or polypeptides, in which the peptide fragment(s) (is) are identical to those of the corresponding natural protein or polypeptide and whose structural fragment(s) comprise(s) a fragment of an oligomer according to the invention.

    专利号:US-2020354404-A1
    优先权日:2019-05-09
    标 题 :Peptidomimetic agents, synthesis and uses thereof
    发明人:AL-ABED YOUSEF
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

    专利号:US-2003191049-A1
    优先权日:2000-01-11
    标 题:Oligomers of nonpeptide restricted mimetics of dipeptides of tripeptides, and the use thereof in the synthesis of synthetic proteins and polypeptides

    专利号:US-10919882-B2
    优先权日:2019-05-09
    标题:Compounds for use in synthesis of peptidomimetics

    专利号:EP-1246837-A2
    优先权日:2000-01-11
    标 题:Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and the use thereof in the synthesis of synthetic proteins and polypeptides

    专利号:US-11414405-B2
    优先权日:2019-05-09
    标 题:Compounds for use in synthesis of peptidomimetics
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    主要参考文献


    1: Moliterno JA, Henry E, Pannullo SC. Corticorelin acetate injections for the treatment of peritumoral brain edema. Expert Opin Investig Drugs. 2009 Sep;18(9):1413-9. doi: 10.1517/13543780903190689. 30(12):5037-42. 67(6):1415-22. doi: 10.1007/s00280-010-1437-3. Epub 2010 Aug 31. 31(9):1182-7. doi: 10.1200/JCO.2012.43.9455. Epub 2013 Feb 4. 44(6):715-26. 32(3):193-215. doi: 10.1358/mf.2010.32.3.1492017. 13(11):1319-25. doi: 10.1586/14737140.2013.852473. Epub 2013 Oct 23. 26(12):1584-93. doi: 10.1177/0269881112458729. Epub 2012 Sep 26. 17(10):3282-92. doi: 10.1158/1078-0432.CCR-10-3203. Epub 2011 Mar 8.
    10: Naing KK, Dewar JA, Leese GP. Megestrol acetate therapy and secondary adrenal suppression. Cancer. 1999 Sep 15;86(6):1044-9.

    合成参考文献


    参考文献:10.1016/j.vascn.2011.06.002
    摘要:Katugampola SD, Fish R, Wood C, Young K, Da Costa Mathews C. Automated blood sampling to identify pharmacodynamics biomarkers of corticotrophin releasing factor receptor 1 antagonism. Journal of Pharmacological and Toxicological Methods. 2011 Sep;64(2):158–63. doi: 10.1016/j.vascn.2011.06.002.
    参考文献:10.1111/j.1369-1600.2011.00329.x
    摘要:Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self‐administration differentially activates dorsal raphe and amygdala corticotropin‐releasing factor systems in rats. Addiction Biology. 2011 Jul 18;17(2):300–8. doi: 10.1111/j.1369-1600.2011.00329.x.
    参考文献:10.1371/journal.pone.0021654
    摘要:Rassouli O, Liapakis G, Lazaridis I, Sakellaris G, Gkountelias K, Gravanis A, Margioris AN, Karalis KP, Venihaki M. A Novel Role of Peripheral Corticotropin-Releasing Hormone (CRH) on Dermal Fibroblasts. PLoS ONE. 2011 Jul 13;6(7):e21654. doi: 10.1371/journal.pone.0021654.
    参考文献:10.1210/en.2005-1273
    摘要:Boorse GC, Kholdani CA, Seasholtz AF, Denver RJ. Corticotropin-releasing factor is cytoprotective in Xenopus tadpole tail: coordination of ligand, receptor, and binding protein in tail muscle cell survival. Endocrinology. 2006 Mar;147(3):1498–507. doi: 10.1210/en.2005-1273.
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