CAS: 6590-93-8; 3,5-Dichlorophenylisothiocyanate

该化合物是一种有机化合物,其特征是附于二氯苯环上的异硫氰酸盐功能组,典型是一种在室温下黄到褐的固体,以其发光的气味闻名;在苯环上的3和5个位置上存在氯原子,这增强了其反应性,使其成为有机合成的有用中间体,特别是在准备各种药品和农用化学剂方面;该化合物在丙酮和二氯甲烷等有机溶剂中溶解,但水溶性有限;必须谨慎处理3,5-二氯苯异硫酸盐,因为它可能对皮肤,眼睛和呼吸系统有毒和刺激;此外,它可能在有水分的情况下进行水解,从而形成相应的硫尿;由于其化学特性,它经常用于研究和工业应用,特别是在与生物活动合成化合物时.

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上下游产品

CAS号463-71-8 硫光气 | CAS号626-43-7 3,5-二氯苯胺 | CAS号5344-44-5 3-氯-5-硝基苯胺 | CAS号618-62-2 3,5-二氯硝基苯 | CAS号107707-33-5 3,5-二氯苯基硫脲 | CAS号89927-42-4 1-amino-3-(3,5-... | CAS号60575-82-8 1-(3,5-dichloro... | CAS号62644-19-3 1-butyl-3-(3,5-... | CAS号62644-20-6 1-(3,5-dichloro...

合成工艺路线路线简述

    📜3,5-二氯硝基苯置于盐酸,乙醇,氯仿,铁粉体系中,化学反应生成 3,5-二氯异硫氰酸苯酯
    参考文献:Dyson; George; Hunter,Journal Of The Chemical Society,1926,P. 3043
    标题:Dyson; George; Hunter,Journal Of The Chemical Society,1926,P. 3043

    海关参考信息

    专利信息


    专利号:US-2007173517-A1
    优先权日:2006-01-20
    标 题:Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    发明人：WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
    权利人:WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
    摘要:Disclosed is an improved multi-step process for preparing a compound of Formula I: n n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

    专利号:US-7470795-B2
    优先权日:2004-07-27
    标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    发明人：WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA
    权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT
    摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

    专利号:US-2009088571-A1
    优先权日:2004-07-27
    标题 :Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

    专利号:US-6414161-B1
    优先权日:2000-08-09
    标 题:Synthesis of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one

    专利号:WO-0212243-A2
    优先权日:2000-08-09
    标 题:SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE

    专利号:JP-2009525964-A
    优先权日:2006-01-20
    标 题 :Synthesis of 6,7-dihydro-5H-imidazo [1,2-a] imidazole-3-sulfonic acid amide

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    主要参考文献

    参考标题:Eco-Friendly Construction Of Spiroquinazolin-2-(Thi)Ones And Quinolin-(Thio)Ureas Via Fe(Iii)-Catalyzed Multi-Component Domino Double [4 + 2] Annulations
    作者:Zhentao Pan,Shuaijun Shi,Xuancheng Yang,Xuqiong Xiao,Wangqin Zhang,Shiliang Wang,Yongmin Ma
    摘要:An Unprecedented Eco-Friendly Multi-Component Domino Approach For The Synthesis Of Spiroquinazolin-2-(Thi)Ones And Quinolin-(Thio)Ureas Via Fe(III)-Catalyzed Domino Double [4 + 2] Cycloadditions Is Described.

    合成参考文献


    参考文献:10.1002/bmc.501
    摘要:Chen S. The factors that influence the elution order for the resolution of amino acids on vancomycin phase using the polar-organic mobile phases after their pre-column derivatization with electrophilic reagents. Biomed Chromatogr. 2005 Jul;19(6):426–33. doi: 10.1002/bmc.501.
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