CAS: 56252-02-9; 2-Hydroxy-9-(4-Hydroxyphenyl)-1H-Phenalen-1-One
该化合物是多种多种有机化合物,在合成药品和精美化学品方面有重要应用,具有高纯度和稳定性,有助于高效的化学转化,其独特的结构特征为开发具有潜在治疗特性的新化合物提供了一个平台.
- 英文名称2-Hydroxy-9-(4-Hydroxyphenyl)-1H-Phenalen-1-One
- 中文名称2-羟基-9-(4-羟基苯基)-1H-萘嵌苯-1-酮
- IUPAC名称2-hydroxy-9-(4-hydroxyphenyl)-1H-phenalen-1-one
- 其它别名Hydroxyanigorufone; 2-Hydroxy-9-(4-Hydroxyphenyl)-1H-Phenalen-1-One; Emenolone; 1H-Phenalen-1-One, 2-Hydroxy-9-(4-Hydroxyphenyl)-
- CAS编号56252-02-9
- MFCD编号:MFCD31746829
- 分子式:C19H12O3分子量:288.3
- 产品CID: 1535432
- 产品分类天然产物 → 酚类
上下游产品
2-Hydroxy-9-(4-Methoxyphenyl)-1H-Phenalen-1-One 65874-44-49-(4-Methoxyphenyl)-1H-Phenalen-1-One 65874-43-3
萘嵌苯酮 Perinaphthenon 548-39-0
合成工艺路线路线简述
📜(E)-3-(Naphthalen-1-yl)Acrylic Acid置于叔丁基过氧化氢,Aluminum (Iii) Chloride,草酰氯,三溴化硼,苄基三甲基氢氧化铵,对甲苯磺酸体系中,用 四氢呋喃,甲醇,二氯甲烷,水,甲苯 作为反应溶剂,化学反应 8.17H,反应生成 2-羟基-9-(4-羟基苯基)-1H-萘嵌苯-1-酮
参考文献:Concise Synthesis Of Natural Phenylphenalenone Phytoalexins And A Regioisomer
标题:Concise Synthesis Of Natural Phenylphenalenone Phytoalexins And A Regioisomer
摘要:Concise Total Syntheses Of The Natural Phytoalexins 2-Hydroxy-8-(4-Hydroxyphenyl)Phenalen-1-One (1),2-Hydroxy-8-(3,4-Dihydroxyphenyl)Phenalen-1-One (2),And Hydroxyanigorufone (4),Together With Regioisomer 3 Are Accomplished In 11 Or 12 Steps. The Synthetic Strategy Features A Friedel Crafts Acylation To Construct The 1H-Phenalen-1-One Tricyclic Core Followed By A Suzuki Cross-Coupling To Obtain The Target Compounds.
DOI:10.1021/acs.Jnatprod.7B00709
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10905674-B2
优先权日:2017-11-22
标题:Method of increasing melatonin synthesis to treat insomnia, ameliorate sleep disturbance and regulate sleep
发明人：LIN YUNG-HSIANG; YU CHIN-HSIU; SU YU-HUNG; LIN SHAN-YU; CHUNG YU-MING
权利人:TCI CO LTD
摘要:A method for at least one of increasing the synthesis of melatonin and promoting the secretion of melatonin is provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I): n nA method for at least one of treating diseases related to neurometabolic disorder, preventing diseases related to neurometabolic disorder, regulating appetite, regulating mood, regulating vasoconstriction, regulating hemostatic function and regulating immune response is also provided, wherein the method comprises administering to a subject in need an effective amount of a compound of formula (I) as described above.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/s0040-4020(97)00490-0
摘要:Luis JG, Lahlou EH, Andrés LS, Echeverri F, Fletcher WQ. Phenylphenalenonic phytoanticipins. New acenaphtylene and dimeric phenylphenalenones from the resistant Musa selected hybrid SH-3481. Tetrahedron. 1997 Jun;53(24):8249–56. doi: 10.1016/s0040-4020(97)00490-0.
参考文献:10.1080/10575639508043208
摘要:Hölscher D, Schneider B. The Biosynthetic Origin of the Central One-Carbon Unit of Phenylphenalenones inAnigozanthos preissii. Natural Product Letters. 1995 Nov;7(3):177–82. doi: 10.1080/10575639508043208.
参考文献:10.1071/ch9751053
摘要:Cooke R, Thomas R. Colouring Matters of Australian Plants. XVIII. Constituents of Anigozanthos rufus. 1975 May 01;28(5):1053–7. doi: 10.1071/ch9751053.
参考文献:10.1007/978-3-031-44746-4_4
摘要:Banadka A, Toppo V, Sudheer WN, Ramakrishnan R, Lakshmaiah VV, Al-Khayri JM, Nagella P. Bioactive Compounds and Biological Activities of Ensete Species. 2024. In: Reference Series in Phytochemistry.
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