CAS: 56162-63-1; 2-Oxo-6-Phenyl-1,2-Dihydropyridine-3-Carboxylic Acid

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📜Methyl 1,2-Dihydro-2-Oxo-6-Phenyl-3-Pyridinecarboxylate置于sodium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 5.0H,反应生成 2-氧代-6-苯基-1,2-二氢-3-吡啶羧酸
参考文献:铑催化的2-吡啶酮的c4选择性c-h烯基化(无痕导向组策略)
标题:铑催化的2-吡啶酮的c4选择性c-h烯基化(无痕导向组策略)
摘要:已经开发了铑催化的3-羧基-2-吡啶酮与苯乙烯的c4-选择性ch烯基化反应.c3位置的羧基用作无痕导向基团,相应的c4-烯基化2-吡啶酮仅通过伴随脱羧作用获得.与报道的方法不同,即使在c5和c6位置可能存在更具反应性的c-h键的情况下,也可以一致地观测到独有的c4选择性.通过使用这种策略,可以通过连续的c-h官能化反应制备多取代的2-吡啶酮.
DOI:10.1021/acs.Orglett.1C00050

专利信息

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.