专利号:CN-107337576-B 优先权日:2017-06-17 标题 :Normal temperature catalytic synthesis of 2-bromo-5-fluorobenzotrifluoride
专利号:US-4968702-A 优先权日:1989-01-17 标 题 :Substituted quinolinecarboxylic acids 发明人:POLETTO JOHN F; POWELL DENNIS W; BOSCHELLI DIANE H 权利人:AMERICAN CYANAMID CO 摘要:Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.
专利号:US-11286268-B1 优先权日:2019-07-02 标题:EIF4E-inhibiting compounds and methods 发明人:SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE 权利人:EFFECTOR THERAPEUTICS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
专利号:CN-113416139-A 优先权日:2021-06-23 标题 :A kind of 4-fluoro-substituted arylamine compound and its synthesis method
[参考文献]: Masaki Ogino, Et Al. Discovery Of A Novel Acyl-Coa: Cholesterol Acyltransferase Inhibitor: The Synthesis, Biological Evaluation, And Reduced Adrenal Toxicity Of (4-Phenylcoumarin)Acetanilide Derivatives With A Carboxylic Acid Moiety. Chem Pharm Bull (Tokyo). 2011;59(11):1369-75.
合成参考文献
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