CAS: 36127-17-0; Methyl 8-Methyl-3-Oxo-8-Azabicyclo[3.2.1]Octane-2-Carboxylate

该化合物是属于来自对流体的两环化合物的热带锥体类的化合物,这种物质具有对流体环结构,其特点是六人碳环内氮原子,其特征为六人碳环内氮原子;存在一个对氧碳基化合物组,表明该分子有一个混合碳基功能组,有助于其再活性和有机合成的潜在应用;该化合物通常是白色到非白色的固体,在有机溶剂中可溶解;其化学特性包括能够承受氯酮和酯的典型反应,例如核脑激素添加和水解. 2-(卡波美特氧)-3-三色酮可能因其结构上与其他生物活性三色衍生物相似而引起对药化学和药理学的兴趣.然而,具体的安全和处理信息应当先从材料安全数据表或有关文献中查阅,然后与该化合物合作.

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相似化合物

1140321-06-7 1822617-22-0 1958050-41-3

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MSDS等安全信息

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合成工艺路线路线简述

  • 合成目标产物 2-Carbomethoxy-3-Tropinone 主要起始原料 Tropinone And Dimethyl Carbonate
  • (文献来源)合成步骤主要原料 Tropinone 和 Dimethyl Carbonate
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氢氧化钾体系中,化学反应生成2甲酯-3-托品酮
参考文献:De352981
标题:De352981

海关参考信息

专利信息


专利号:US-6486323-B1
优先权日:1998-09-30
标 题:Process for producing optically active tropinonemonocarboxylic acid derivative
发明人：NODE MANABU; NAKAMURA SOICHI; NAKAMURA DAISAKU
权利人:NIHON MEDIPHYSICS CO LTD
摘要:An optically active tropinonemonocarboxylic acid ester derivative useful as an intermediate for synthesis of optically active tropane derivatives was obtained by reacting succindialdehyde with an organic amine and acetonedicarboxylic acid ester to obtain a tropinonedicarboxylic acid ester derivative, and then subjecting this derivative to enzyme-catalyzed asymmetric dealkoxy-carbonylation. Since anhydroecgonine methyl ester derived from the optically active tropinone-monocarboxylic acid ester derivative by reduction and dehydration had the same direction of optical rotation as in the case of anhydroecgonine methyl ester obtained from natural cocaine, it was proved that the obtained optically active tropinonemonocarboxylic acid ester derivative had the same absolute configuration as that of natural cocaine. The yield of the optically active tropinonemonocarboxylic acid ester derivative from the asymmetric dealkoxycarbonylation was 30 to 50 mol %, and its optical purity was 70 to 97% ee. In addition, it was found that a crystalline optically active anhydroecgonine carboxylic acid ester derivative can be obtained by reducing and then dehydrating the optically active tropinonemonocarboxylic acid ester derivative and that its optical purity can easily be increased by recrystallization.

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合成参考文献


摘要:Collier, S. J., Science of Synthesis, (2007) 20, 693.
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