CAS: 2914-17-2; Calcium,Ethanolate

上下游产品

ethanol sodium ethanolate calcium calcium hydridetetraethoxy orthosilicate

专利信息

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.

专利号:WO-2020117135-A1
优先权日:2018-12-04
标 题:A process for preparation of 1h-pyrazolo[3,4-d] pyrimidine derivatives
发明人：HAAS PHILIPP DANIEL; STECKEL ANDREAS HARTWIG; BELLUR ATICI ESEN; ALTUNDAS RAMAZAN; OZTURK AYDIN BUSRA; SECEN HASAN; AYDIN BUSRA NUR
权利人:DEVA HOLDING AS
摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.

专利号:US-3910965-A
优先权日:1971-11-29
标 题 :Process for the preparation of 2-formylcyclopentane derivatives
发明人：SAKAI KIYOSHI; KOJIMA KOICHI; YUSA TAKASHI; KATANO HAMAKO
权利人:SANKYO CO
摘要:A process for the preparation of 2-formylcyclopentane derivatives having the formula WHEREIN A represents a straight or branched alkylene group having 1*8 carbon atoms, Z represents cyano group, carbamoyl group, carboxyl group or an alkoxycarbonyl group having 1*6 carbon atoms in the alkyl moiety and R represents a tetrahydropyranyl group or an alkoxyalkyl group having 1*6 carbon atoms in each alkyl moiety or its optical isomer or the racemic mixture thereof which comprises conntacting a 2hydroxymethylcyclopentane derivative having the formula WHEREIN A, Z and R are the same as above or its optical isomer or the racemic mixture thereof with an oxidizing agent in the presence of a solvent at the temperature ranging from -30*C to room temperature. The 2-formylcyclopentane derivatives are useful as intermediates for synthesis of prostaglandin F Alpha .

专利号:US-7879388-B2
优先权日:2004-10-28
标题 :Methods for production and use of synthetic hydroxyapatite and fluorapatite nanorods, and superstructures assembled from the same
发明人：CLARKSON BRIAN H; CHEN HAIFENG
权利人:UNIV MICHIGAN
摘要:Disclosed herein are methods directed toward the synthesis of ordered structures of hydroxyapatite and hydroxyapatite derivatives. More specifically, disclosed herein is a method of preparing ordered hydroxyapatite nanorod structures including the steps of suspending calcium and phosphate in a solvent, adjusting the pH to above 5, and heating to a temperature sufficient to support formation of the ordered hydroxyapatite nanorod structures. In some cases, the methods may include ethylenediamine tetraacetic acid or ethylenediamine tetraacetic acid derivatives. Also disclosed are methods that additionally involve a step of coating hydroxyapatite nanorods with a protein or an amphiphile such as a surfactant or polymer.