CAS: 286370-15-8; 1-(2-Chloro-4-((6,7-Dimethoxyquinazolin-4-yl)Oxy)Phenyl)-3-Propylurea

上下游产品

2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)-oxy]aniline bis(trichloromethyl) carbonate sodium hydrogencarbonateN-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N-methoxymethyl-N'-propylurea

📜2-Chloro-4-((6,7-Dimethoxyquinazolin-4-yl)Oxy)Aniline 以64的收率获得krn 633; N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲
参考文献:Quinoline Derivatives And Quinazoline Derivatives
标题:Quinoline Derivatives And Quinazoline Derivatives
摘要:本发明的目的是提供具有抗肿瘤活性且不改变细胞形态的化合物.公开了由式(i)表示的化合物及其药学上可接受的盐和溶剂和包含该化合物的药物组合物:其中x和z各自独立地表示ch或n;R1至r3表示h,取代烷氧基,未取代烷氧基或类似物;R4表示h;R5至r8表示h,卤素,烷基,烷氧基,烷基硫基,硝基或氨基,但要求r5至r8不能同时表示h;R9和r10表示h,烷基或烷基羰基;R11表示烷基,烯基,炔基或苄基.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-11617804-B2
优先权日:2014-07-18
标题:Hyaluronic acid-based nanoparticles as biosensors for imaging-guided surgery and drug delivery vehicles and methods associated therewith
发明人：MOHS AARON MICHAEL; HILL TANNER KINKADE; KELKAR SNEHA SANJAY; KRIDEL STEVE
权利人:UNIV WAKE FOREST
摘要:The present invention relates to intraoperative fluorescent imaging (IFI) used both pre-clinically using in-vivo models, as well as clinically to map sentinel lymph nodes in breast cancer, skin cancer, GI cancer, lung cancer, prostate cancer and several other cancers. IFI can be used to image solid tumors both non-specifically in hepatobiliary and breast cancers as well as in prostate and ovarian cancer. In one embodiment, two-dimensional resolution to 10 μm 2 is possible with optical imaging, significantly higher than other imaging modalities. n In one embodiment, the present invention relates to a series of self-assembled nanoparticles using HLA (hyaluronic acid) as both a polymeric backbone as well as targeting ligand. In some embodiments, the present invention relates to the synthesis of HLA conjugates, and the effect of variation of the hydrophobic ligand structure and conjugation level on nanoparticle self-assembly, size, ICG loading efficiency, and ICG fluorescence quenching and reactivation.

专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound

专利号:US-11299491-B2
优先权日:2018-11-16
标 题:Synthesis of key intermediate of KRAS G12C inhibitor compound

专利号:US-2025206735-A1
优先权日:2018-11-16
标题:Synthesis of key intermediate of kras g12c inhibitor compound