CAS: 251316-98-0; (2S,3R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-Methylpentanoic Acid

相似化合物

2250198-69-5 13139-16-7 138775-22-1

上下游产品

L-isoleucine 9-fluorenylmethyl N-succinimidyl carbonate (9-fluorenyl)methyl pentafluorophenyl carbonate N-(9-Fluorenylmethoxycarbonyl)-D-alloisoleucine methyl esterFm°C-Ile-OTDO ((1S,2S)-1-Chlor°Carbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

📜氯甲酸-9-芴基甲酯,L-异亮氨酸 以96%的收率获得
参考文献:Jian,Dunlong;Jian,Zhigang;Long,Kanhou,Chzhunshan Dasyueh Syuehbao/tszyzhan Kehsyuehban,29,(1990) N,S. 43-47
标题:Jian,Dunlong;Jian,Zhigang;Long,Kanhou,Chzhunshan Dasyueh Syuehbao/tszyzhan Kehsyuehban,29,(1990) N,S. 43-47

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-2024076311-A1
优先权日:2020-12-28
标 题:Method for synthesizing peptide thioesters and head-to-tail amide cyclic peptide thereof
发明人：CHEN ZHILI; TAO TONGQIANG; TAN BAOFENG; ZHANG XIN
权利人:JIANGSU GENSCRIPT BIOTECH CO LTD
摘要:A method for synthesizing peptide thioesters and a head-to-tail amide cyclic peptide thereof, which belongs to the technical field of chemical pharmaceuticals and fine chemical preparation. The method comprises the following steps: (1) using resin A as a carrier and using a solid-phase synthesis strategy to obtain a resin peptide; (2) cutting the resin to obtain a fully protected peptide; (3) performing an esterification reaction with p-chlorophenyl thiophenol in a TCFH/alkali condensation system to generate p-chlorophenyl thioester; (4) removing the protecting group to obtain a peptide thioester; and (5) further cyclizing to obtain a head-to-tail cyclic peptide. The preparation of the thioester peptide and the head-to-tail amide cyclic peptide provides a simple technical route with wide universality and a high yield, and has a wide range of applications in the technology of chemical pharmaceuticals and fine chemical preparation.