CAS: 18995-35-2; 1-(Tert-Butoxy)-4-Chlorobenzene

上下游产品

CAS号6669-13-2 叔丁基苯醚 | CAS号507-20-0 氯代叔丁烷 | CAS号106-48-9 对氯苯酚 | CAS号106-39-8 对氯溴苯 | CAS号865-47-4 叔丁醇钾

叔丁基苯醚置于kaolin,Sodium Chlorite,Manganese(III) Acetylacetonate体系中,用 二氯甲烷 用作溶剂,化学反应 1.17H,以93%的收率获得对氯苯基叔丁基醚
参考文献:高岭土辅助芳香氯化和溴化
标题:高岭土辅助芳香氯化和溴化
摘要:潮湿的高岭土用 Naclo2 和 Mn(Acac) 催化 C6H5Or(r=c1-C8 烷基,丁基,烯丙基,环己基,苄基)到 4-Xc6H4Or(分别为 X=cl 和 Br)的区域选择性和高产氯化和溴化在温和和中性条件下,分别在不存在和存在 Nabr 的情况下在 Ch2Cl2 中反应生成3.
Doi:10.1039/a804043E

专利信息

专利号:US-8829184-B2
优先权日:2010-04-15
标题:Intermediates useful for the synthesis of pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD
权利人:HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD; SPIROGEN SARL
摘要:A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds.

专利号:US-2013035484-A1
优先权日:2010-04-15
标 题:Intermediates useful for the synthesis of pyrrolobenzodiazepines

专利号:WO-2011128650-A1
优先权日:2010-04-15
标 题:Intermediates useful for the synthesis of pyrrolobenzodiazepines

专利号:US-9102704-B2
优先权日:2011-10-14
标 题:Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; TIBERGHIEN ARNAUD
权利人:SPIROGEN SARL; SPIROGEN SARL
摘要:A compound of formula I wherein: R 7 is selected from: OR A , where R A is selected from C 1-4 saturated alkyl, optionally substituted by phenyl, which may bear a chloro substituent, pyridyl and furanyl; chloro; NH 2 ; —CH 2 —O—C(â•?O)Me; R 8 is OProt o , where Prot o is a silicon-based oxygen protecting group orthogonal to R c ; R 9 is selected from H, methyl and methoxy; R s is selected from CF 3 , (CF 2 ) 3 CF 3 , CH 3 and (formula 2) and R c is selected from: (i) C(â•?O)—OR C1 , where R C1 is a saturated C 1-4 alkyl group; (ii) —CH 2 —O—C(â•?O)R C2 , where R C2 is methyl or phenyl; (iii) CH 2 —O—Si—(R Si1 )(R Si2 )(R Si3 ), where R Si1 , R Si2 , R Si3 are independently selected from C 1-6 a saturated alkyl group and a phenyl group; and (iv) C(—YR C3 )(—YR C4 ) where each Y is independently O or S, and where R C3 and R C4 are independently a saturated C 1-4 alkyl group, or together form a C 2-3 alylene.

专利号:EP-2558445-B1
优先权日:2010-04-15
标 题 :Intermediates useful for the synthesis of pyrrolobenzodiazepines

专利号:WO-2013053872-A1
优先权日:2011-10-14
标题 :Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines