CAS: 18344-51-9; 2-Amino-3-Methyl-5-Nitropyridine

该化合物是一种有机化合物,属于类,是的衍生物;该化合物具有氨基氨基(-NH2)和附于环的硝基(-NO2),具体地说分别位于2和5个位置,而3个位置则由一个甲基群体占据;该物质在室温下一般是黄到褐色的固体,在极地溶剂中溶解;氨基和硝基功能组的存在都具有独特的化学反应性,使其在各种合成应用中有用,包括制药和农用化学品生产;此外,其结构允许潜在的氢结合和与其他分子的相互作用,影响其在化学反应中的行为;安全数据表明,应对该物质时,应注意潜在的毒性和环境危害.

英文名称2-Amino-3-Methyl-5-Nitropyridine
中文名称3-甲基-5-硝基吡啶-2-胺
IUPAC名称3-methyl-5-nitropyridin-2-amine
其它别名2-氨基-3-甲基-5-硝基吡啶 10G; Tris(4-Fluorophenyl)Phosphane
CAS编号18344-51-9
MFCD编号:MFCD03095060
EINECS号:623-204-7
分子式:C6H7N3O2
分子量:153.14
产品CID: 942914
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考;;
InChIKey: JLPYUDJJBGYXEZ-UHFFFAOYSA-N
InChI=1S/C6H7N3O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3,(H2,7,8)…
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数1.0

相似化合物

7598-26-7 21901-40-6 1230637-09-8

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼损伤类别1
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
急性毒性类别4(吸入)
急性毒性类别4(经皮)
警示词Danger(危险)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
防范说明P264-P270-P280-P330-P501
危险等级8
UN编号1759.0
危险品标志Xn,Xi
包装等级Ⅲ
安全声明36/37/39-26-22-39-36-37
危险类别码36/37/38-20/21/22-41-22
WGK Germany1

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2-Amino-3-Methyl-5-Nitropyridine 主要起始原料 2-Amino-3-Picoline
(文献来源)合成步骤主要原料 2-Amino-3-Picoline

N-(3-甲基吡啶-2-基)硝酰胺以甲醇用作溶剂,化学反应 0.5H,以19.4%的收率获得2-氨基-3-甲基-5-硝基吡啶
参考文献:Sepiol,Jadwiga; Tomasik,Piotr,Acta Chimica Hungarica,1986,Vol. 121,# 4,P. 333-338
标题:Sepiol,Jadwiga; Tomasik,Piotr,Acta Chimica Hungarica,1986,Vol. 121,# 4,P. 333-338

海关参考信息

2933310010-吡啶
2904209090-其他仅含硝基或亚硝基衍生物
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

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优先权日:2006-08-29
标题:Heterocyclic fxr binding compounds
发明人：KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS
权利人:PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

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优先权日:2020-04-29
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优先权日:2020-04-29
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