CAS: 1449029-77-9; (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl 2-Ethoxy-1-((2'-(N'-Hydroxycarbamimidoyl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate

英文名称(5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl 2-Ethoxy-1-((2'-(N'-Hydroxycarbamimidoyl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate
中文名称美阿沙坦钾杂质26
IUPAC名称(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
其它别名Azilsartan Amidoxime; (5-Methyl-2-Oxo-2H-1,3-Dioxol-4-yl)Methyl 2-Ethoxy-1-[[4-[2-(N-Hydroxycarbamimidoyl)Phenyl]Phenyl]Methyl]-1H-1,3-Benzodiazole-7-Carboxylate; Azilsartan Impurity 53; (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl (Z)-2-Ethoxy-1-((2'-(N'-Hydroxycarbamimidoyl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate; (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl 2-Ethoxy-1-((2'-(N-Hydroxycarbamimidoyl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate; 1H-Benzimidazole-7-Carboxylic Acid, 2-Ethoxy-1-[[2'-[(Hydroxyamino)Iminomethyl][1,1'-Biphenyl]-4-Yl]Methyl]-, (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl Ester; Azilsartan Potassium Medoxomil Amidoxime Dioxolene Ester Impurity
CAS编号1449029-77-9
FDA UNII编号:E2YY68FE9S
分子式:C29H26N4O7分子量:542.55
产品CID: 684604
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: CQSKEJHMXPTBLT-UHFFFAOYSA-N
InChI=1S/C29H26N4O7/c1-3-37-28-31-23-10-6-9-22(27(34)38-16-24-17(2)39-29(35)40-24)25(23)33(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26(30)32-36/h4-14,36H,3,15-16H2,1-2
计算化学: 氢键受体数9.0氢键供体数2.0可旋转键数10.0

物理性质

熔点171 - 174°C
沸点753.3±70.0 °C(预测)
密度1.39±0.1 g/cm3(预测)
pKa:6.77±0.69(预测)
溶解性DMSO (Slightly), Water (Slightly)
外观形态白色至类白色固体
储存条件防潮, -20°C 冰箱, 在惰性气其中
产品应用该化合物用于作为血管二型受体阻塞器的AZILSARTAN KAMEDOXOMIL的中间体.

MSDS等安全信息

上下游产品

1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid 4-chloromethyl-5-methyl-1,3-dioxol-2-one methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate Azilsartan medoxomil (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl 2-ethoxy-1-[(2'-{N'-[(ethoxycarbonyl)oxy]carbamimidoyl}-biphenyl-4-yl)-methyl]-1H-benzimidazole-7-carboxylate (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(N'-{[(4-nitrophenoxy)carbonyl]oxy}carbamimidoyl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

合成工艺路线路线简述

合成目标产物 1449029-77-9 主要起始原料 (Z)-2-Ethoxy-3-((2'-(N'-Hydroxycarbamimidoyl)Biphenyl-4-yl)Methyl)-3H-Benzo[d]Imidazole-4-Carboxylic Acid And 4-Cloromethyl-5-Methyl-1,3-Dioxol-2-One
(文献来源)合成步骤主要原料 (Z)-2-Ethoxy-3-((2'-(N'-Hydroxycarbamimidoyl)Biphenyl-4-yl)Methyl)-3H-Benzo[d]Imidazole-4-Carboxylic Acid 和 4-Cloromethyl-5-Methyl-1,3-Dioxol-2-One

📜2-乙氧基-1-((2-(N-羟基甲脒基)-[1,1-联苯]-4-基)甲基)-1H-苯并[d]咪唑-7-羧酸甲酯置于水,Potassium Carbonate,Sodium Hydroxide体系中,用四氢呋喃,水,N,N-二甲基甲酰胺用作溶剂,化学反应 10.0H,反应生成美阿沙坦钾杂质26
参考文献:Process For The Preparation Of Azilsartan Medoxomil Or Pharmaceutically Acceptable Salts Thereof
标题:Process For The Preparation Of Azilsartan Medoxomil Or Pharmaceutically Acceptable Salts Thereof
摘要:本发明涉及一种用于制备阿利沙坦酯酸美托莫明或其药用可接受盐的方法.