CAS: 13290-96-5; Dimethyl 5-Nitroisophthalate

相似化合物

1955-46-0 618-88-2 99-27-4

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CAS号618-88-2 5-硝基间苯二甲酸 | CAS号1459-93-4 间苯二甲酸二甲酯 | CAS号13438-30-7 5-硝基异酞酰氯 | CAS号67-56-1 甲醇 | CAS号99-27-4 5-氨基间苯二甲酸二甲酯 | CAS号76820-34-3 N,N'-双(2,3-二羟丙基... | CAS号76801-93-9 5-氨基-2,4,6-三碘-N... | CAS号76820-35-4 5-氨基-NN′-双(2.3-... | CAS号88116-47-6 1-N,3-N-bis(2-h... | CAS号4445-59-4 [1,1'-联苯]-3,5-二羧酸 | CAS号46828-05-1 3,5-双(甲氧基羰基)异氰酸苯酯 | CAS号60166-97-4 N,N-Bis-(1,3-di...

5-硝基异酞酰氯 以 甲醇 用作溶剂,化学反应生成5-硝基间苯二甲酸二甲酯
参考文献:Ureylene Naphthalene Sulfonic Acids
标题:Ureylene Naphthalene Sulfonic Acids
摘要:尿素基对称苯基双羰基亚胺取代苯基羰基亚胺四萘聚磺酸苯甲酸盐,以及硝基和氨基取代苯基双羰基亚胺取代苯甲酰胺基苯二羰基二萘聚磺酸苯甲酸盐,这些是制备具有互补抑制活性的活性尿素的中间体.

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-8962887-B2
优先权日:2009-07-21
标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
发明人：HOMESTAD OLE MAGNE
权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.

专利号:US-9688614-B2
优先权日:2013-12-06
标 题:Alternative acetylation process in the synthesis of non-ionic X-ray contrast agents
发明人：SAANUM INGER DAGNY; HAALAND TORFINN; KALLEBERG RITA HESKESTAD
权利人:GE HEALTHCARE AS
摘要:An alternative acetylation process for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents, is described. The process can be performed on an industrial scale to produce Compound A with improved purity and improved yields compared to the established processes.

专利号:US-4002664-A
优先权日:1973-06-09
标题 :Manufacture of dimethylaminobenzenecarboxylic acid esters
发明人：QUADBECK-SEEGER HANS-JUERGEN; HOCH HELMUT
权利人:BASF AG
摘要:Dimethylaminobenzenecarboxylic acid esters are produced by reaction of nitrobenzenecarboxylic acid esters with formaldehyde and hydrogen under pressure in the presence of a hydrogenation catalyst containing metals of atomic numbers 24 to 29 and of a weak acid, at temperatures from 35° to 150° C. The products are starting materials for the synthesis of dyes, especially of crystal violets, and of reactive dyes and pesticides.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.