CAS: 132388-58-0; H-Asn(Trt)-Oh

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CAS号132388-57-9 N-苄氧羰基-N'-三苯甲基-... | CAS号76-84-6 三苯基甲醇 | CAS号70-47-3 L-天冬酰胺 | CAS号132388-59-1 Fm°C-N-三苯甲基-L-天冬酰胺 | CAS号132388-59-1 Fm°C-N-三苯甲基-L-天冬酰胺 | CAS号132388-64-8 L-天门冬二氨酸 | CAS号132388-57-9 N-苄氧羰基-N'-三苯甲基-... | CAS号132388-68-2 叔丁氧羰基-N-beta-三苯...

三苯基甲醇置于palladium On Activated Charcoal 硫酸,氢气,乙酸酐体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,反应生成N'-(三苯甲基)-L-天冬酰胺
参考文献:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
标题:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
摘要:羧酰胺官能团可以通过在冰醋酸中与三苯甲醇和乙酸酐进行酸催化反应来三苯甲基化.天冬酰胺和谷氨酰胺的ω-三苯甲基可被tfa裂解,但对水溶液中的强无机酸以及亲核试剂和碱稳定.在肽合成中,它非常适合与叔丁基类型的侧链保护结合使用.
Doi:10.1016/s0040-4039(00)74872-6

专利信息

专利号:US-2025066393-A1
优先权日:2021-12-24
标题 :Amine-protecting group
发明人：XU PENGYU; YONEYAMA SHIN
权利人:SYNCREST INC
摘要:An object of the present invention is to provide novel amine-protecting groups useful for the synthesis of special amino acids. Provided is an amine-protecting group.

专利号:US-12433936-B2
优先权日:2021-04-12
标 题:High-purity adrenocorticotropic hormone analogue and a large-scale preparation method thereof
发明人：MENG JUNDONG; YANG TAO; WU FEIFEI; ZHANG HAONING
权利人:NANJING HANXIN PHARMACEUTICAL TECH CO LTD
摘要:Polypeptide preparation methods of preparing high-purity ACTH (human sequence) or analogue and large-scale preparation method thereof are described. The main steps include: amino acids are coupled from the C-terminal to the N-terminal by Fmoc solid-phase synthesis method to obtain the crude ACTH (human sequence) or analogue peptidyl-resin with protective groups, wherein the reaction temperature of C-15 peptide synthesis is 40-60° C. After cleavage and precipitation, the crude product of ACTH (human sequence) or analogue is obtained, and then the high-purity product is obtained by liquid chromatography. The chromatographic purity of ACTH (human sequence) or analogue prepared by the invention is more than 99%, the stability is good, and the yield of the target peptide is ≥63%.

专利号:US-11419919-B1
优先权日:2021-04-12
标题 :High-purity adrenocorticotropic hormone, analogue and a large-scale preparation method thereof
发明人：MENG JUNDONG; Rui Kangning; LIU BIN; HAN YUANYUAN; CHEN SONG; ZHANG HAONING
权利人:NANJING HANXIN PHARMACEUTICAL TECH CO LTD
摘要:The invention belongs to the technical field of polypeptide preparation methods, and in particular relates to a high-purity ACTH (human sequence) or analogue and large-scale preparation method thereof. The main steps include: amino acids are coupled from the C-terminal to the N-terminal by Fmoc solid-phase synthesis method to obtain the crude ACTH (human sequence) or analogue peptidyl-resin with protective groups, wherein the reaction temperature of C-15 peptide synthesis is 40-60° C. After cleavge and precipitation, the crude product of ACTH (human sequence) or analogue is obtained, and then the high-purity product is obtained by liquid chromatography. The chromatographic purity of ACTH (human sequence) or analogue prepared by the invention is more than 99%, the stability is good, and the yield of the target peptide is ≥63%.

专利号:US-RE49961-E
优先权日:2016-10-21
标 题:Solid phase peptide syntheses
发明人：COLLINS JONATHAN M
权利人:CEM CORP
摘要:An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

专利号:CN-111285921-B
优先权日:2020-02-12
标 题:Liquid-phase total synthesis method of BDK auxiliary group and plecanatide and analogues based on BDK auxiliary group

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.