CAS: 110529-22-1; (S)-Alpha,Alpha-Diphenylmethylprolinol

上下游产品

CAS号152326-82-4 ethyl (S)-(-)-2... | CAS号113557-12-3 benzyl (S)-(-)-... | CAS号5211-23-4 N-Z-L-脯氨酸甲酯 | CAS号100-58-3 苯基溴化镁 | CAS号137496-68-5 2-(hydroxy(diph... | CAS号77581-28-3 (S)-1-ethyl 2-m... | CAS号147-85-3 脯氨酸 | CAS号50-00-0 甲醛 | CAS号22348-32-9 (r)-(+)-α,α-二苯基脯氨醇

📜Boc-L-脯氨酸甲酯置于lithium Aluminium Tetrahydride,Magnesium体系中,用 四氢呋喃 用作溶剂,化学反应 25.0H,反应生成α,α-二苯基-N-甲基-L-脯氨醇
参考文献:氘标记相关的有机催化硝基醛醇反应
标题:氘标记相关的有机催化硝基醛醇反应
摘要:在碱性和有机催化条件下,已经完成了氧化氘中的硝基链烷烃的氘标记反应和随后的硝基醛反应,从而以高收率和高氘含量提供了氘标记的β-硝基醇.使用易去除的碱性树脂wa30,可通过硝基烷与各种亲电试剂的反应平稳地获得β氘代的β硝基醇.此外,在奎宁衍生的有机催化剂存在下,使用硝基甲烷和α-酮酸酯作为亲电试剂的不对称硝基醛醇反应可提供所需的具有高对映选择性的β-氘代硝基醇衍生物.
Doi:10.1002/adsc.201701224

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-7692019-B2
优先权日:2000-12-04
标 题:Methods for the stereoselective synthesis of substituted piperidines
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.

专利号:US-6867305-B2
优先权日:1996-12-03
标题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; STACHEL SHAWN J; LEE CHUL BOM; CHAPPELL MARK D; WU ZHICAL
权利人:SLOAN KETTERING INST CANCER; UNIV COLUMBIA
摘要:The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

专利号:US-2002052028-A1
优先权日:2000-08-09
标题:Bio-intermediates for use in the chemical synthesis of polyketides

专利号:US-2002058817-A1
优先权日:1996-12-03
标题 :Synthesis of epothilones, intermediates thereto and analogues thereof