CAS: 1071-23-4; O-Phosphorylethanolamine

该化合物是一种自然形成的有机化合物,是细胞膜中一种主要磷素,即磷酸乙胺生物合成的一种前体,其分子结构以一个与乙醇胺有关的磷酸盐组为特征,使其能够参与关键的代谢途径,包括脂代谢和细胞信号,该化合物因其在研究应用中的作用而受到重视,特别是在研究膜生物起源和磷酸盐新陈代谢方面的作用,其高纯度和稳定性使其适合生物化学和药物调查,还因其参与细胞过程而探索了磷酸乙胺的潜在治疗用途.

结构式图片

相似化合物

329223-23-6 107-73-3 1169692-38-9

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号141-43-5 2-氨基乙醇 | CAS号14662-76-1 (2-hydroxy-ethy... | CAS号151-56-4 氮丙啶 | CAS号4167-12-8 diphenyl methyl... | CAS号497-25-6 2-恶唑烷酮 | CAS号102313-50-8 (2-diphenoxypho... | CAS号2002-24-6 盐酸乙醇胺 | CAS号65314-76-3 2-aminoethyl di... | CAS号64-19-7 冰醋酸 | CAS号3036-18-8 2-aminoethoxy-[... | CAS号141-43-5 2-氨基乙醇

合成工艺路线路线简述

    二苯基甲基氯化锡置于氨,水体系中,化学反应生成乙醇胺磷酸酯
    参考文献:Plimmer; Burch,Biochemical Journal,1937,Vol. 31,P. 404
    标题:Plimmer; Burch,Biochemical Journal,1937,Vol. 31,P. 404

    专利信息


    专利号:US-9708354-B2
    优先权日:2013-03-15
    标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
    发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
    权利人:CERENIS THERAPEUTICS HOLDING SA
    摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

    专利号:US-7943594-B2
    优先权日:2002-07-10
    标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
    发明人:SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.

    专利号:US-2006211083-A1
    优先权日:2005-01-21
    标题:Products and processes for in vitro synthesis of biomolecules
    发明人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
    权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
    摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.

    专利号:US-10407454-B2
    优先权日:2016-01-07
    标 题 :Defined enzymatic synthesis of lipid A analogs
    发明人:XIAO XIRUI; KHOSLA CHAITAN
    权利人:UNIV LELAND STANFORD JUNIOR
    摘要:Provided herein include methods and compositions for synthesis of Lipid IV A and derivatives thereof, using a defined set of pathway enzyme, which may be isolated and used to reconstitute all or part of the pathway in a cell-free reaction.

    专利号:US-6171614-B1
    优先权日:1996-10-15
    标 题 :Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
    发明人:CHAIKOF ELLIOT L; SUN LIJUN
    权利人:UNIV EMORY
    摘要:The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.

    专利号:EP-2690438-A1
    优先权日:2012-07-24
    标题:Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from toxoplasma gondii and their application as diagnostic markers and vaccines
    发明人:AZZOUZ NAHID; GOETZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to the synthesis of compounds derived from glycosylphosphatidylinositol (GPI) glycolipids from Toxoplasma gondii and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis and for use as a vaccine against diseases caused by infection with T. gondii.
    辽宁博美医药科技有限公司
    ⚠️ 未注册 · 未认证企业
    ⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
    数据来源于公开网络搜索,平台未作核实,请自行辨别。
    🏢敬请 企业认领
    🏬开设公司展台
    📢获取免费会员权益
    🎖️点亮专属注册企业标签
    📇展现公司完整信息 样本查看立即注册认领 →
    网址: http://www.biosunpharm.com
    企业联系电话:024-24524889,18640309171👤
    📞辽宁博美医药科技有限公司 ⚠️参考联系方式
    联系人:李伟
    电话:024-24524889,18640309171
    手机:18640309171
    传真:024-24524889
    邮箱:sales@biosunpharm.com
    通信地址: 本溪经济开发区药都研发中心
    邮编: 110015
    🆔 联系时候可告知是从"百琢研"平台获取的信息.
    ⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

    地址:本溪经济开发区药都研发中心
    ⚠️ 未注册 · 未认证企业
    注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别
    ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
    第 1 / 1 页

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hullin-Matsuda F, Makino A, Murate M, Kobayashi T. Probing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin and aegerolysin proteins. Biochimie. 2016 Nov;130:81-90. doi: 10.1016/j.biochi.2016.09.020. Review. doi: 10.1111/j.1574-6976.2011.00267.x. Review.
    3: Guo L, Davies SS. Bioactive aldehyde-modified phosphatidylethanolamines. Biochimie. 2013 Jan;95(1):74-8. doi: 10.1016/j.biochi.2012.07.010. Review. Review. doi: 10.1016/j.bbamem.2015.10.012. Review. Review. doi: 10.1089/ars.2014.6154. Review.
    8: Sullivan SM, Doukas J, Hartikka J, Smith L, Rolland A. Vaxfectin: a versatile adjuvant for plasmid DNA- and protein-based vaccines. Expert Opin Drug Deliv. 2010 Dec;7(12):1433-46. doi: 10.1517/17425247.2010.538047. Review. doi: 10.1111/1462-2920.12956. Review. doi: 10.1016/j.plipres.2015.02.003. Review. doi: 10.1182/blood-2012-04-402826. Review.

    合成参考文献


    参考文献:10.1203/00006450-200205000-00005
    摘要:Bayir H, Kagan VE, Tyurina YY, Tyurin V, Ruppel RA, Adelson PD, Graham SH, Janesko K, Clark RS, Kochanek PM. Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Res. 2002 May;51(5):571–8. doi: 10.1203/00006450-200205000-00005.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知