专利号:US-9708354-B2 优先权日:2013-03-15 标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins 发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK 权利人:CERENIS THERAPEUTICS HOLDING SA 摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
专利号:US-7943594-B2 优先权日:2002-07-10 标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans 发明人:SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.
专利号:US-2006211083-A1 优先权日:2005-01-21 标题:Products and processes for in vitro synthesis of biomolecules 发明人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA 权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA 摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.
专利号:US-10407454-B2 优先权日:2016-01-07 标 题 :Defined enzymatic synthesis of lipid A analogs 发明人:XIAO XIRUI; KHOSLA CHAITAN 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Provided herein include methods and compositions for synthesis of Lipid IV A and derivatives thereof, using a defined set of pathway enzyme, which may be isolated and used to reconstitute all or part of the pathway in a cell-free reaction.
专利号:US-6171614-B1 优先权日:1996-10-15 标 题 :Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof 发明人:CHAIKOF ELLIOT L; SUN LIJUN 权利人:UNIV EMORY 摘要:The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.
专利号:EP-2690438-A1 优先权日:2012-07-24 标题:Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from toxoplasma gondii and their application as diagnostic markers and vaccines 发明人:AZZOUZ NAHID; GOETZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN 权利人:MAX PLANCK GESELLSCHAFT 摘要:The present invention relates to the synthesis of compounds derived from glycosylphosphatidylinositol (GPI) glycolipids from Toxoplasma gondii and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis and for use as a vaccine against diseases caused by infection with T. gondii.
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合成参考文献
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