专利号:US-6063919-A 优先权日:1998-08-14 标题:Process for the synthesis of exochelins 发明人:GAUDIOSO LARRY A; WEGLARZ MICHAEL A 权利人:KEYSTONE BIOMEDICAL INC 摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.
专利号:US-7619116-B2 优先权日:2003-12-17 标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation 发明人:DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM 权利人:PRODUCTS CHIMIQUES AUXILIAIRES 摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
专利号:US-8729277-B2 优先权日:2009-04-06 标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives 发明人:YANG HU; BARALT EDUARDO J 权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO 摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.
专利号:US-2008112874-A1 优先权日:2006-08-31 标 题:Method for producing calcium phosphate powders using an auto-ignition combustion synthesis reaction 发明人:BURKES DOUGLAS E; MOORE JOHN J; AYERS REED A 权利人:BURKES DOUGLAS E; MOORE JOHN J; AYERS REED A 摘要:A method for making high purity, multiphasic calcium phosphate powders using an Auto-Ignition Combustion Synthesis (AICS) reaction of a calcium salt, a phosphate salt and a fuel is provided. In the method provided, energy released from the AICS reaction between the calcium salt, phosphate salt and fuel ignites at temperatures much lower than the actual phase transformation temperatures and reaches a high temperature rapidly enough for synthesis of the desired product to occur, without the requirement for coprecipitation, an external heat source for calcination and/or additional steps for removing undesired precursors from the desired final product.
专利号:WO-2013120711-A1 优先权日:2012-02-17 标 题 :Process for manufacturing a methanol synthesis catalyst 发明人:ROBLES MACIAS LUIS ANGEL; CURULLA-FERRE DANIEL; FERREIRA CRISTINA; SANTIAGO REDONDO MARTA; STOICA GEORGIANA 权利人:TOTAL RAFFINAGE CHIMIE 摘要:The present invention pertains to a process for the manufacture of a CuO/ZnO/Al 2 O 3 catalyst, which may be used in the synthesis of methanol from syngas. It also pertains to the catalyst thus obtained, which offers a high external surface area, fine copper oxide crystallites and a high copper surface after reduction.
专利号:EP-0542969-B1 优先权日:1991-06-04 标 题:Biodegradable particulate vector and method of synthesis 发明人:SAMAIN DANIEL; DE MIGUEL IGNACIO; MENIALI JAOUAD; IOUALALEN KARIM; DING LI; CERVILLA MONIQUE; RIEUMAJOU VALERIE; DELRIEU PASCAL; IMBERTIE LAURENT 权利人:BIOVECTOR THERAPEUTICS SA 摘要:A biodegradable particulate vector is disclosed and is characterized in that it comprises: a nucleus consisting of a cross-linked polysaccharide or oligosaccharide matrix to which ionic ligands are attached; a first semi-permeable lipid layer linked to the nucleus by covalent bonds; a second layer of amphiphilic compounds linked to the first lipid layer by hydrophobic interactions. A method for synthesis of said vector is also disclosed.
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