CAS: 10466-61-2; H-Leu-Nh2.Hcl

相似化合物

10466-60-1 80970-09-8 687-51-4

上下游产品

CAS号26400-34-0 FA-Gly-Phe-NH2 | CAS号84969-54-0 H-Leu-NH2*formate | CAS号7517-19-3 L-亮氨酸甲酯盐酸盐 | CAS号77313-68-9 Z(OMe)-Leu-NH2 | CAS号26607-51-2 N-CBZ-D-丙氨酸 | CAS号18323-56-3 Z-Ala-Leu-NH2 | CAS号70533-96-9 b°C-l-亮氨酰胺 | CAS号13171-93-2 Z-GLY-GLY-PHE-OH | CAS号84969-56-2 Z-Gly-Gly-L-Phe... | CAS号100929-57-5 DES-TYR1-LEUCIN... | CAS号69193-15-3 benzyl N-[2-[[(... | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号7535-72-0 Z-Gly-Leu-NH2 | CAS号1145-80-8 |N|-苄氧羰基-L-丝氨酸

H-Leu-Nh2*formate置于盐酸体系中,用 1,4-二氧六环 用作溶剂,化学反应生成L-亮氨酰胺盐酸盐
参考文献:Filippi; Biondi; Filira,Farmaco,Edizione Scientifica,1983,Vol. 38,# 10,P. 713-724
标题:Filippi; Biondi; Filira,Farmaco,Edizione Scientifica,1983,Vol. 38,# 10,P. 713-724

专利信息

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-2024199680-A1
优先权日:2021-04-02
标 题:Synthesis of fluorinated cyclic dinucleotides
发明人：AN CHIHUI; FIER PATRICK S; HIRAGA KAORI; LIU ZHIJIAN; MARSHALL NICHOLAS M; MCINTOSH JOHN; MILLER STEVEN P; MOORE JEFFREY C; MURPHY GRANT S; OBLIGACION JENNIFER V; PAN WEILAN; PENG FENG; SALEHI MARZIJARANI NASTARAN; WINSTON MATTHEW S
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2′-deoxy-2′-fluoro-5′-O—[(R)-hydroxymercaptophosphinyl]-P-thio-β-D-arabino-adenylyl-(3′→5′)-3′-deoxy-3′-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2λ 5 ,10λ 5 -5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

专利号:US-6495693-B2
优先权日:1996-11-22
标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-2021236859-A1
优先权日:2020-05-22
标题 :Synthesis of fluorinated nucleotides

专利号:EP-4153189-A1
优先权日:2020-05-22
标 题 :Synthesis of fluorinated nucleotides

专利号:US-5563044-A
优先权日:1990-12-10
标题:Process for the enzymatic preparation of GRF(1-44)NH2
发明人：FELIX ARTHUR M; HEIMER EDGAR P
权利人:HOFFMANN LA ROCHE
摘要:GRF(1-44)-NH 2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH 2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical pathway to the clinically important GRF(1-44)-NH 2 compound.