CAS: 102065-86-1; Azetidin-3-Amine

相似化合物

102065-89-4 193269-78-2 217806-26-3

上下游产品

CAS号102065-90-7 1-(二苯基甲基)-3-氨基氮...

📜1-苄基氮杂啶-3-胺置于palladium On Activated Charcoal,氢气体系中,用 甲醇,水 用作溶剂,70.0 °C,1.0 Mpa 条件下,反应 5.0H,以91.3%的收率获得3-氨基氮杂环丁烷二盐酸盐
参考文献:一种3-氨基氮杂环丁烷的合成方法
标题:一种3-氨基氮杂环丁烷的合成方法
摘要:本发明属于有机合成技术领域,具体涉及一种3‑氨基氮杂环丁烷的合成方法,该方法采用1‑苯甲基‑3‑吖啶丁醇盐酸盐与甲磺酰氯在乙腈中磺化反应取代羟基得到中间体ⅰ,然后氨解,进而让氨基取代磺酰基得到中间体ⅱ;最后将中间体ⅱ加氢还原,得到最终产物3‑氨基氮杂环丁烷,本发明使用1‑苯甲基‑3‑吖啶丁醇盐酸盐作为反应的起始原料,降低生产成本,反应所需的条件比较容易控制,试剂要求不多,产品质量稳定可控.

专利信息

专利号:WO-0063168-A1
优先权日:1999-04-16
标题 :Synthesis of azetidine derivatives
发明人：CHEN ZHENGMING; KOLB HATMUTH C; RICHARDSON PAUL; HUANG ZHI-MIN
权利人:COELACANTH CHEMICAL CORP; CHEN ZHENGMING; KOLB HATMUTH C; RICHARDSON PAUL; HUANG ZHI MIN
摘要:The present invention provides compound having formula (I), useful as building blocks for combinatorial libraries and methods of making such compounds. Also provided is a novel process for synthesizing such compounds. In addition, the present invention includes products made by these processes.

专利号:US-9868746-B2
优先权日:2012-02-23
标题:Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; TARR JAMES C; SALOVICH JAMES M; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-4943641-A
优先权日:1984-02-27
标 题:3-aminoazetidine, its salts, process for their preparation and intermediates of synthesis
发明人：NISATO DINO; FRIGERIO MARCO
权利人:SANOFI SA
摘要:The 3-aminoazetidine, its salts, new intermediates of formula wherein X' represents hydrogen or a protecting group and both X'' represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' not and both X'' being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.

专利号:US-5994575-A
优先权日:1996-04-16
标 题 :Phenylenediamines and process for preparing the same
发明人：YAZAKI AKIRA; YOSHIDA JIRO; NIINO YOSHIKO
权利人:WAKUNAGA PHARMA CO LTD
摘要:Phenylenediamines represented by general formula (1): ##STR1## wherein R represents an alkyl group or an optionally substituted aralkyl group, X 1 represents a hydrogen atom or a halogen atom, and X 2 represents a halogen atom; salts thereof, and a process for preparing the same. The compounds are useful as intermediates for synthesis of pyridonecarboxylic acid derivatives useful as antibacterial agents.

专利号:US-6080760-A
优先权日:1997-06-18
标题:Alpha 1A adrenergic receptor antagonists
发明人：PATANE MICHAEL A; BOCK MARK G
权利人:MERCK & CO INC
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

专利号:WO-9857639-A1
优先权日:1997-06-18
标题 :ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS
发明人：PATANE MICHAEL A; BOCK MARK G
权利人:MERCK & CO INC; PATANE MICHAEL A; BOCK MARK G
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha la adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.