CAS: 101987-86-4; Ethyl 3-(3-Chloro-2,4,5-Trifluorophenyl)-3-Oxopropanoate

相似化合物

98349-24-7 94695-50-8 3516-87-8

上下游产品

3-氯-2,4,5-三氟苯甲酸 3-Chloro-2,4,5-Trifluorobenzoic Acid 101513-77-3
3-氯-2,4,5-三氟苯甲酰氯 3-Chloro-2,4,5-Trifluorobenzoyl Chloride 101513-78-4

Diethyl 2-(3-Chloro-2,4,5-Trifluorobenzoyl)Propanedioate置于对甲苯磺酸体系中,用 水 用作溶剂,化学反应 5.0H,反应生成3-氯-2,4,5-三氟苯甲酰乙酸乙酯
参考文献:含有肟功能部分的1-(6-氨基-3,5-二氟吡啶-2-基)氟喹诺酮衍生物的合成,抗分枝杆菌和抗菌活性.
标题:含有肟功能部分的1-(6-氨基-3,5-二氟吡啶-2-基)氟喹诺酮衍生物的合成,抗分枝杆菌和抗菌活性.
摘要:合成了一系列含有肟功能部分的新型1-(6-氨基-3,5-二氟吡啶-2-基)氟喹诺酮衍生物,并对其生物学活性进行了评估.我们的结果表明,化合物9A-9C对mtb H37Rv Atcc 27294(mic:3.81-7.13Mug / Ml)和对甲氧西林敏感的金黄色葡萄球菌菌株(mic:<0.008-0.5Mug / Ml)均具有相当大的活性.
Doi:10.1016/j.Bmcl.2016.03.050

专利信息

专利号:US-4885386-A
优先权日:1988-10-28
标题 :Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
发明人：WEMPLE JAMES N; KARRICK GREGORY L; SPENCE FLOYD G
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.

专利号:JP-2886908-B2
优先权日:1988-10-28
标题:Improved synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

专利号:US-5994575-A
优先权日:1996-04-16
标 题 :Phenylenediamines and process for preparing the same
发明人：YAZAKI AKIRA; YOSHIDA JIRO; NIINO YOSHIKO
权利人:WAKUNAGA PHARMA CO LTD
摘要:Phenylenediamines represented by general formula (1): ##STR1## wherein R represents an alkyl group or an optionally substituted aralkyl group, X 1 represents a hydrogen atom or a halogen atom, and X 2 represents a halogen atom; salts thereof, and a process for preparing the same. The compounds are useful as intermediates for synthesis of pyridonecarboxylic acid derivatives useful as antibacterial agents.

专利号:EP-0366149-B1
优先权日:1988-10-28
标题 :Improved process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

专利号:EP-0366149-A1
优先权日:1988-10-28
标 题 :Improved process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

专利号:IE-63335-B1
优先权日:1988-10-28
标题 :Improved process for the synthesis of 3-chloro-2 4 5-trifluorobenzoic acid