专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:WO-2018232298-A1 优先权日:2017-06-16 标题:Anti-fungals compounds targeting the synthesis of fungal sphingolipids
专利号:US-2020207705-A1 优先权日:2017-06-16 标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
专利号:WO-9615111-A1 优先权日:1994-11-15 标 题:Method and intermediates for the synthesis of korupensamines
专利号:US-2024124392-A1 优先权日:2017-06-16 标 题:Anti-fungals compounds targeting the synthesis of fungal sphingolipids
专利号:US-5543523-A 优先权日:1994-11-15 标 题 :Method and intermediates for the synthesis of korupensamines 发明人:HOYE THOMAS R 权利人:UNIV MINNESOTA 摘要:Activated isoquinolines and naphthalenes are disclosed which are useful to prepare korupensamines, michellamines and analogs thereof.
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合成参考文献
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