CAS: 614-76-6; 2-Bromoacetanilide

上下游产品

acetyl chloride 2-bromoaniline Acetanilid acetic anhydride N-(2-bromo-6-nitro-phenyl)-acetamide 2-bromo-4-nitroaniline N-(2-bromo-4-nitro-phenyl)-acetamide 2',4'-dibromoacetanilide

📜N-乙酰苯胺置于n-溴代丁二酰亚胺(Nbs),Cobalt Acetylacetonate,三氟乙酸,Silver(L) Oxide体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 16.0H,以86%的收率获得产物2'-溴乙酰苯胺
参考文献:钴(II)催化的苯甲酸酯的区域选择性c-h卤化†
标题:钴(II)催化的苯甲酸酯的区域选择性c-h卤化†
摘要:本文报道了钴催化的区域选择性ch卤化方法.这项工作的重点是对苯甲酸酯的高选择性c-h官能化,这将产生高产率,多功能且实用的卤化产物.由此,以高度选择性的方式实现了许多富电子和电子贫乏的酸酐的溴化,氯化和碘化.还描述了有关反应途径的机理研究.
DOI:10.1039/c8Ob01448E

专利信息

专利号:US-7652137-B2
优先权日:2003-03-06
标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
发明人：GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.

专利号:US-9790207-B2
优先权日:2015-09-04
标题 :Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods
发明人：IVACHTCHENKO ALEXANDRE VASILIEVICH; MITKIN OLEG DMITRIEVICH
权利人:IVACHTCHENKO ALEXANDRE VASILIEVICH; IVASHCHENKO ANDREY ALEXANDROVICH; SAVCHUK NIKOLAY FILIPPOVICH; ALLA CHEM LLC
摘要:Compound represented by formula 1: n nor a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein:n nR1 is hydrogen, tert-butoxycarbonyl,n n nwhere R11 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy, and arrows (â†?) indicate the position of substituents attachment;n nR2 is hydrogen, halogen, or C 1 -C 4 alkyl;n nR3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl;n n n n n n n n n n n n n where R41 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (â†?) indicate the position of substituents attacment.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:CN-101234996-B
优先权日:2008-02-29
标题:A kind of green synthesis method of ketazine

专利号:CN-109422662-B
优先权日:2017-08-25
标题:Synthesis method of N-phenyl acetamide compound

专利号:CN-111039796-A
优先权日:2019-12-12
标 题 :Novel synthesis method of 4' -chloro-2-aminobiphenyl