CAS: 598-52-7; N-Methylthiourea

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S-Methyl N-Methyl Dithiocarbamate置于ammonium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 N-甲硫脲
参考文献:新型hsp70抑制剂n,N'-二取代硫脲衍生物的设计,合成和生物学评估
标题:新型hsp70抑制剂n,N'-二取代硫脲衍生物的设计,合成和生物学评估
摘要:作为新型的热激蛋白70(hsp70)抑制剂,基于atpase域(核苷酸结合域,Nbd)的x射线结构设计并合成了n,N'-二取代的硫脲衍生物.atpase活性抑制试验表明,这些化合物有效抑制hsp70 Atpase活性.结果表明,化合物370/371/374/379/380 // 392/394/397/404/405和407可以抑制hsp70 Atpase的转换,且抑制率较高:50.42,38.46,50.45,44.12,47.13,200μm中分别为50.50,40.95,65.36,46.23,35.78和58.37.在bt474乳腺癌细胞系中观测到与化合物379和化合物405的拉帕替尼具有显着的协同作用.r 1.0拉帕替尼耐药细胞系.hsp70抑制剂可能被开发为抗药性癌症治疗中的协同药物.
DOI:10.1016/j.Ejmech.2016.04.042

专利信息

专利号:US-11759760-B2
优先权日:2016-01-12
标题:Apparatus and process for the automated chemical synthesis of compounds
发明人：BODE JEFFREY WILLIAM; WANNER BENEDIKT MATTHIAS; CHEN KUANG-YEN; PATTABIRAMAN VIJAYA; NICHOLS PAULA LOUISE
权利人:ETH ZUERICH
摘要:Provided is an apparatus for the automated synthesis of at least one chemical compound including: at least one cartridge including at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound; at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, and at least one third compartment for purifying the at least one synthesized compound; at least one reaction container for providing the compounds to be fed into at least one of the compartments of the cartridge and/or collecting the reaction product from at least one of the compartments of the cartridge; at least one solvent container at least two flow path selecting valves and at least one pump.

专利号:US-8314090-B2
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives
发明人：HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON
权利人:HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON; VENTIRX PHARMACEUTICALS INC; ARRAY BIOPHARMA INC
摘要:The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

专利号:US-2023312596-A1
优先权日:2020-07-20
标题:Method for large-scale synthesis of tetrodotoxin
发明人：WANG GUANGYIN; LI XIAOMING; WANG CHENGXI; HUANG PING; BAI HUA; LAI LIANG; GUO PENG; JIANG BIAO; ZHU WENFENG
权利人:SHANGHAI SHENGPING MEDICAL EQUIPMENT CO LTD; SHANGHAI VASTPRO TECH DEVELOPMENT CO LTD; ZHEJIANG BOXIAO BIOPARMACEUTICAL CO LTD
摘要:The present invention provides a method for biological and chemical synthesis of tetrodotoxin, specifically comprising the following steps: using cheap and easily available benzyl acetate as a raw material, and performing biological fermentation to obtain an optically pure intermediate ((5S, 6R)-5, 6-dihydroxycyclohexa-1, 3-dienyl) methyl acetate (formula I); and performing a series of chemical conversions on the intermediate to finally obtain tetrodotoxin at a purity of 95% or more without purifying the product. The present invention has the potential of large-scale production, and is an excellent alternative to the existing extraction method from a pufferfish.

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-4627968-A
优先权日:1984-09-10
标 题 :Synthesis of crystalline aluminosilicate with alkylurea or alkylthiourea
发明人：KAI TADASHI
权利人:ASAHI CHEMICAL IND
摘要:In the synthesis of a crystalline aluminosilicate by heating an aqueous mixture containing a silica source, an alumina source and an alkali metal source, at least one compound selected from lower alkylureas and lower alkylthioureas is permitted to co-exist with the mixture.

专利号:WO-2011156355-A1
优先权日:2010-06-09
标题 :Production method of phenyl guanidine salts and their intermediates
发明人：JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN
权利人:KAINOS MEDICINE INC; JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN
摘要:This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.