CAS: 455-91-4; 3'-Fluoro-4'-Methoxyacetophenone

上下游产品

CAS号321-28-8 2-氟苯甲醚 | CAS号75-36-5 乙酰氯 | CAS号403-14-5 3'-氟-4'-羟基苯乙酮 | CAS号77-78-1 硫酸二甲酯 | CAS号100-06-1 对甲氧基苯乙酮 | CAS号108-24-7 乙酸酐 | CAS号29650-44-0 (2-fluorophenyl... | CAS号367-12-4 2-氟苯酚 | CAS号75-15-0 二硫化碳 | CAS号7446-70-0 氯化铝 | CAS号403-14-5 3'-氟-4'-羟基苯乙酮 | CAS号350-27-6 2-Bromo-1-(3-fl... | CAS号403-20-3 3-氟-4-甲氧基苯甲酸 | CAS号452-11-9 3-氟-4-甲氧基苯酚 | CAS号105321-49-1 1-(3-氟-4-甲氧基苯基)乙烷胺 | CAS号170570-77-1 4,4-difluoro-1-... | CAS号169590-41-4 地拉考昔 | CAS号70862-63-4 4,4,4-trifluoro...

2-氟苯酚置于aluminum (Iii) Chloride,Potassium Carbonate,三乙胺体系中,用 甲基叔丁基醚,氯苯,丙酮 作为反应溶剂,化学反应 6.25H,反应生成 3-氟-4-甲氧基苯乙酮
参考文献:炸薯条重排:关键的氟结构单元3-氟-4-甲氧基苯甲酰氯和1,2-二乙氧基-3-氟苯的可扩展合成
标题:炸薯条重排:关键的氟结构单元3-氟-4-甲氧基苯甲酰氯和1,2-二乙氧基-3-氟苯的可扩展合成
摘要:路易斯酸催化的2-氟苯基乙酸酯(3)的弗里斯重排以千克规模进行.以工业上可行的方式分离得到的邻 5和对 4异构体.然后将化合物4转化为氟化的结构单元3-氟-4-甲氧基苯甲酰氯(1),同时将化合物5以高产率转化为1,2-二乙氧基-3-氟苯(2).
DOI:10.1016/j.Tetlet.2014.02.119

专利信息

专利号:US-5098602-A
优先权日:1988-05-11
标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements
发明人：HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA
权利人:NIPPON MINING CO
摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k
专利号:CN-112521290-A
优先权日:2020-11-30
标题 :Synthesis of intermediate product β-aminoketoene compound and method for synthesizing fluoroalkylpyrazole compounds from this intermediate product

专利号:US-5910597-A
优先权日:1995-05-25
标题 :Process for preparing 3-haloalkyl-1H-pyrazoles
发明人：ZHI BENXIN; NEWAZ MURAD
权利人:SEARLE & CO
摘要:An efficient synthesis of 3-haloalkyl-1H-pyrazoles, suitable for adoption in a safe, large-scale process, has been developed.

专利号:US-7501430-B2
优先权日:2006-04-17
标题:RAF inhibitors and their uses
发明人：LAPIERRE JEAN-MARC; NAMDEV NIVEDITA D; ASHWELL MARK A; FRANCE DENNIS S; WU HUI; HUTCHINS PATRICK M; TANDON MANISH; LIU YANBIN; LINK JEFF S; ALI SYED M; BRASSARD CHRIS J; NICEWONGER ROBB B; FILIKOV ANTON; CARAZZA REBECCA J
权利人:ARQULE INC
摘要:The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAF V600E . The compounds are useful for the treatment of cell proliferative disorders such as cancer.

专利号:US-9701686-B2
优先权日:2009-12-04
标题:Tricyclopyrazole derivatives
发明人：DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.