CAS: 39878-65-4; O-Methyl-D-Tyrosine

该化合物是一种氨基酸衍生物,其特点是在D-tyrosine的苯丙基氢氧基组的正方位上存在一个甲氧基组(-OCH3),这种改变改变了其溶性及其与母体化合物相比的再活性.O-Me乙-D-tyrosine通常是一种白色的脱白晶体粉,在水和酒精等极地溶剂中溶解.它经常用于生物化学研究,特别是在与...

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7635-29-2 53267-93-9 6230-11-1

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合成工艺路线路线简述

    📜4-甲氧基-L-苯丙氨酸置于葡萄糖,Nicotinamide Adenine Dinucleotide Phosphate,氯化铵体系中,用 Aq. Buffer 作为反应溶剂,化学反应 24.0H,以76%的收率获得产物o-甲基-D-酪氨酸
    参考文献:利用工程化的d-氨基酸脱氢酶的对映体纯d-芳基丙氨酸的单一生物催化剂合成
    标题:利用工程化的d-氨基酸脱氢酶的对映体纯d-芳基丙氨酸的单一生物催化剂合成
    摘要:基于相应的α-酮酸通过由工程脱氢酶和辅因子回收装置组成的重组全细胞系统的还原胺化反应,已开发出一种实用,有效的芳香族d-氨基酸生物催化合成方法.结果表明,在制备规模上,该反应在多种底物上均具有出色的对映选择性(>=98%)和非常好的收率.另外,解析了变体酶的结构以使观测到的反应速率合理化.工程化的全细胞催化剂还通过与对映体互补脱氨酶结合使用,来介导外消旋混合物和更便宜的l-氨基酸产生的d-苯丙氨酸衍生物.
    DOI:10.1002/adsc.201600682

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    专利信息


    专利号:US-9550000-B2
    优先权日:2011-09-09
    标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
    发明人：ROBINSON SIMON P; YU MING
    权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
    摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

    专利号:US-2014328756-A1
    优先权日:2011-09-09
    标题:Compositions, methods, and systems for the synthesis and use of imaging agents

    专利号:US-2017266326-A1
    优先权日:2011-09-09
    标题:Compositions, methods, and systems for the synthesis and use of imaging agents

    专利号:WO-2013036869-A2
    优先权日:2011-09-09
    标 题:Compositions, methods, and systems for the synthesis and use of imaging agents

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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
    [参考文献]: Deqiang Zhang, Et Al. Structure-Based Design Of Mutant Methanococcus Jannaschii Tyrosyl-Trna Synthetase For Incorporation Of O-Methyl-L-Tyrosine. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6579-84.
    [参考文献]: Jason W Chin, Et Al. An Expanded Eukaryotic Genetic Code. Science. 2003 Aug 15;301(5635):964-7.
    [参考文献]: Jed N Lampe, Et Al. Ligand-Induced Conformational Heterogeneity Of Cytochrome P450 Cyp119 Identified By 2D Nmr Spectroscopy With The Unnatural Amino Acid (13)C-P-Methoxyphenylalanine. J Am Chem Soc. 2008 Dec 3;130(48):16168-9.
    [参考文献]: Jed N Lampe, Et Al. Two-Dimensional Nmr And All-Atom Molecular Dynamics Of Cytochrome P450 Cyp119 Reveal Hidden Conformational Substates. J Biol Chem. 2010 Mar 26;285(13):9594-9603.

    合成参考文献


    摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 408.
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