CAS: 3513-81-3; 2-Methylenepropane-1,3-Diol

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3775-29-9 116700-73-3 4370-80-3

上下游产品

CAS号1871-57-4 3-氯-2-氯甲基丙烯 | CAS号6707-12-6 5-降冰片烯-2,2-二甲醇 | CAS号3775-29-9 2-亚甲基丙烷-1,3-二乙酰氧基 | CAS号40364-84-9 2-hydroxymethyl... | CAS号19184-65-7 2-溴甲基-2-羟甲基-1,3-丙二醇 | CAS号1607-00-7 1,3-Propanediol... | CAS号113859-64-6 2-methyleneprop... | CAS号1779-49-3 甲基三苯基溴化膦 | CAS号74181-34-3 2,2-二甲基-1,3-二恶烷-5-酮 | CAS号7732-18-5 水 | CAS号27441-79-8 2-(phenylmethox... | CAS号78-85-3 2-甲基丙烯醛 | CAS号3290-74-2 5-methylidene-2... | CAS号1871-57-4 3-氯-2-氯甲基丙烯 | CAS号87597-80-6 2-(triphenylsta... | CAS号57859-50-4 acetic acid,2-m... | CAS号510730-17-3 2-(trityloxymet... | CAS号3775-29-9 2-亚甲基丙烷-1,3-二乙酰氧基 | CAS号55849-58-6 3,9-Dimethylide...

2-亚甲基丙烷-1,3-二基二乙酸酯置于甲醇,Potassium Carbonate体系中,化学反应生成2-亚甲基-1,3-丙二醇
参考文献:Synthesis Of Isofagomine And A New C6 Pyrrolidine Azasugar With Potential Biological Activity
标题:Synthesis Of Isofagomine And A New C6 Pyrrolidine Azasugar With Potential Biological Activity
摘要:描述了一种高效的不对称合成异法戈敏的方法,该方法基于一种含有三个不同羟基功能的前体.在关键的烷基化步骤中,副产物转化为(2S,3R,4R)-2,4-双(羟甲基)-3-羟基吡咯烷,这是一种新的c6吡咯烷氮糖,能够抑制酵母中的α-葡萄糖苷酶.
Doi:10.1055/s-2008-1078280

专利信息

专利号:US-2009247754-A1
优先权日:2008-03-25
标 题:Method of preparing huperzine a and derivatives thereof
发明人：UNDERINER GAIL; GIBSON FRANK; HE LINLI; MEERA HARIHARA SUBRAMANIAN; GNANADEEPAM JESUDOSS MERCY; SAIGANESH RAMANATHAN; TUDHOPE STEPHEN R; AZADI-ARDAKANI MANOUCHEHR
权利人:DEBIOPHARM SA
摘要:The present invention is related to the synthesis of huperzine A. The synthesis includes a variety of process steps that increase productivity, reduce safety concerns, and allow for increasing production of compounds of desired optical isomer. The inventive methods may encompass a single improved reaction step that may be incorporated into a known reaction process for synthesizing huperzine A or a derivative thereof to improve the overall reaction. The inventive methods also encompass complete synthesis methods for preparing huperzine A or a derivative thereof.

专利号:US-2004116724-A1
优先权日:1996-12-06
标 题:Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
发明人：KINNEY WILLIAM A; JONES STEVEN; ZHANG XUEHAI; RAO MEENA N; BULLIARD MICHEL; MECKLER HAROLD; LEE NANCY
摘要:A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.

专利号:US-7563877-B2
优先权日:2006-03-02
标题 :Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
发明人：XU GUOYOU; GAI YONGHUA; WANG GUOQIANG; OR YAT SUN; WANG ZHE
权利人:ENANTA PHARM INC
摘要:The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivative known as EDP-182 (IX-a). In particular, the present invention relates to processes and intermediates for the preparation of O-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine:

专利号:US-6610866-B2
优先权日:1996-12-06
标 题 :Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
发明人：KINNEY WILLIAM A; JONES STEVEN; ZHANG XUEHAI; RAO MEENA N; BULLIARD MICHEL; MECKLER HAROLD; LEE NANCY
权利人:MAGAININ PHARMA
摘要:A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.

专利号:US-9023813-B2
优先权日:2011-04-13
标题:Synthesis and use of glycoside derivatives of propofol
发明人：SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN
权利人:SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN; NUTEK PHARMA LTD
摘要:The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug propofol analogs. This invention relates to a method for the production of a broad group of glycosylated propofol carbohydrate derivatives.

专利号:US-2010298504-A1
优先权日:2007-09-19
标题 :Amphiphilic polymer and processes of forming the same
发明人：Janczewski Dominik; TOMCZAK NIKODEM; KHIN YIN WIN; HAN MINGYONG; VANCSO JULIUS
权利人:AGENCY SCIENCE TECH & RES
摘要:Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.